#Japan #Exosomes #FANCL #Kanagawa #Goat Milk

Fancl's Innovative Goat Milk Extract for Skin Improvements

Fancl has embarked on a remarkable journey towards enhancing skin health by exploring the mechanisms behind aging and the efficacy of cosmetic ingredients. Their commitment has led to groundbreaking discoveries regarding a specific type of microRNA (miRNA)—miR-365a—which plays a crucial role in mitigating skin aging. Notably, Fancl has extracted exosomes from goat milk, which are rich in miR-365a. These exosomes have demonstrated the ability to inhibit skin cell aging while simultaneously promoting the production of vital proteins such as collagen and elastin.

Recently, the company conducted a significant study to evaluate the efficacy of their goat milk extract containing exosomes. This involved a continuous application test with a specially formulated lotion over a period of eight weeks. The results were compelling: participants showed a considerable improvement in both the appearance of nasolabial folds (more commonly known as laugh lines) and the moisture content of their skin. The findings were presented at the 3rd Annual Japanese Cosmetic Technicians Association Academic Conference in December 2025.

Study Methodology

The trial involved women aged between 40 and 60 years. Participants were instructed to apply lotion enriched with goat milk extract to one side of their face and a placebo lotion without the extract to the other side, with applications twice a day. The skin conditions were evaluated before the trial and at intervals of four and eight weeks.

A measurement of changes in nasolabial fold volume was a key assessment criterion, allowing researchers to quantify improvements in skin depth and surface area effectively. Remarkably, the group using the goat milk extract lotion experienced a significant reduction in the volume of nasolabial folds compared to those using the non-enriched lotion after eight weeks.

Additionally, improvements were noted in the stratum corneum's moisture content, paralleling the results observed with the nasolabial folds. These findings suggest that the exosomes from goat milk extract play a pivotal role in enhancing collagen and elastin production and thereby contribute to a more youthful appearance.

Implications for Future Development

The confirmation of improved nasolabial fold volume through the use of the goat milk extract lotion heralds the potential for effective anti-aging solutions that can combat wrinkles and sagging skin. Moreover, the increase in moisture content illuminates the possibility that the exosomes act at the cellular level, a hypothesis the company plans to explore further. Through ongoing research, Fancl aims to elucidate the complete mechanisms at work, optimizing these findings for a broader range of skincare products.

As Fancl continues to innovate in the realm of anti-aging, their commitment to researching skin aging and effective ingredients remains steadfast. Their developments mark essential advancements in the field, transforming scientific research into practical solutions that cater to consumer needs.

Expert Opinion

"This confirmation of the efficacy of exosomal mechanisms in human skin marks a significant milestone in our research. It underscores our dedication to addressing real skin concerns through scientific inquiry. These findings serve as a stepping stone, linking cellular and genetic insights to tangible improvements in skin conditions," said Alisa Toyama, a researcher at Fancl’s Skincare Science Group.

In conclusion, Fancl's latest venture into goat milk exosome technology embodies their relentless pursuit of skincare innovation, ultimately aiming to foster healthier, younger-looking skin for consumers worldwide.