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Jordan S. Orange Rejoins Children's Hospital of Philadelphia

In an exciting development for pediatric healthcare, Children's Hospital of Philadelphia (CHOP) welcomes back Dr. Jordan S. Orange as the new Pediatrician-in-Chief and Chair of the Department of Pediatrics. Dr. Orange, who previously completed his pediatric residency at CHOP, rejoined the institution in September 2025, bringing with him an impressive background in pediatric research and healthcare leadership.

Dr. Orange is renowned globally for his contributions to the understanding of pediatric primary immunodeficiencies and the immunobiology of natural killer cells. His extensive training includes an MD/PhD and an Allergy/Immunology fellowship at Boston Children's Hospital, making him a versatile and accomplished professional in the field. Before returning to CHOP, he served as the Reuben S. Carpentier Professor and Department Chair at Columbia University, where he led innovative research endeavours. His journey has also seen him in prestigious roles at Baylor College of Medicine and Texas Children's Hospital.

The reentry of Dr. Orange at CHOP is met with enthusiasm from both staff and patients. Joseph W. St. Geme III, MD, CHOP's Physician-in-Chief, expressed high confidence in Dr. Orange's capabilities, asserting that his dedication to patient care and scientific innovations will enhance positive outcomes for children and the healthcare community at large.

Dr. Orange’s return is not merely a homecoming; it marks a commitment to taking CHOP's renowned pediatric care to new heights. He acknowledges the institution's established excellence and aims to leverage its impressive infrastructure and expertise to deliver exceptional patient care. His vision includes a focus on groundbreaking research initiatives, especially related to rare diseases, which can significantly impact children’s health.

Throughout his career, Dr. Orange has been at the forefront of immunology research, authoring over 350 publications and leading efforts funded by the National Institutes of Health (NIH). Among his achievements, he has identified 29 novel genetic diseases, further emphasizing the critical need for cutting-edge healthcare solutions in pediatrics.

Dr. Orange’s notable accolades include the Judson Daland Prize and the E. Mead Johnson Award, graphically indicating his prominence in pediatric research. He is not only a MERIT awardee from the National Institute of Allergy and Infectious Diseases but also an esteemed member of several distinguished medical societies, highlighting his contributions to scientific understanding within pediatrics.

In his new role at CHOP, Dr. Orange aims to continue and expand the hospital's research initiatives, contributing to its legacy of innovation in pediatric care. He stated, “Advancing our work at CHOP is a profound honor, as it allows me to contribute to a remarkable institution renowned for its excellence in patient care, medical breakthroughs, and research.”

As Children's Hospital of Philadelphia continues to be a leading institution in pediatric health, the return of Dr. Orange embodies a reinvigorated mission to embrace innovation and excellence. Given his impressive past, there is great anticipation surrounding the new frontiers in pediatric care that may emerge from CHOP under Dr. Orange's stewardship.

CHOP, founded in 1855, stands as the first pediatric hospital in the nation. Through its commitment to exceptional patient care, impactful research, and training the next generation of pediatric healthcare providers, CHOP remains at the forefront of pediatric medicine. With Dr. Orange at the helm, the future looks promising for continued advancements in this vital field.