#None #mRNA Therapeutics #Sequence Engineering #GMP Strategies

Webinar Overview

Join us for an enlightening free webinar focused on the enhancement of mRNA performance through the innovative applications of sequence engineering and GMP integration strategies. Scheduled for December 16, 2025, at 2 PM EST, this session promises to be an invaluable resource for those involved in mRNA therapeutic developments.

Event Details

This webinar, presented by industry experts including Jessica Madigan, Manika Bhondeley, and Molly McGlaughlin, aims to provide a comprehensive understanding of how specific sequence-level decisions impact mRNA performance. Participants will gain insights on how to optimize codon usage and UTR design to improve IVT efficiency, translational output, and overall manufacturability of mRNA constructs.

Key Topics Covered

1. Impact of Sequence Design: Attendees will learn about the vital role sequence design plays in influencing key parameters such as mRNA stability, yield, and performance in therapeutic settings. The discussion will cover how rational sequence engineering, particularly through codon optimization and UTR selection, can significantly affect transcription efficiency and downstream processes.

2. Challenges in Development: Participants will explore common challenges in aligning mRNA sequence design with GMP production standards. Misalignment can often result in delays and hinder the overall success of mRNA therapeutic projects. This session will equip attendees with strategies to avoid such pitfalls and facilitate smoother transitions from research and development to clinical manufacturing.

3. Harmonizing Workflows: The speakers will outline effective methodologies for improving handoffs and workflows among research development (RD), chemistry, manufacturing, and control (CMC), and GMP teams. By fostering collaboration among these groups, participants will learn how to reduce technical risks and enhance the likelihood of successful IND (Investigational New Drug) applications.

4. Direct Practical Insights: Attendees can expect actionable insights on evaluating codon and UTR choices, recognizing sequence-level attributes that influence IVT efficiency, and understanding how early data packages can streamline regulatory readiness. Concrete examples will illustrate the process of aligning optimization with production capabilities.

Importance of the Webinar

As mRNA therapeutics continue to gain prominence in the medical field, understanding the complexities of sequence engineering and GMP compliance is more crucial than ever. Developers are faced with heightened expectations for the efficacy and reliability of their products amidst evolving regulatory landscapes. This webinar serves as a vital platform for communicating best practices and fostering a collaborative environment that encourages knowledge sharing across the industry.

Register Today

Don’t miss the chance to gain crucial insights that can shape the future of mRNA therapeutics. Register for the webinar to enhance your knowledge of mRNA performance optimization and GMP integration strategies. For more details and to secure your spot, visit the webinar registration page.

About Xtalks

Xtalks is a leading provider of informative webinars and digital resources designed for professionals in the life science, healthcare, and medical device industries. Each year, Xtalks attracts a global audience of industry practitioners seeking to stay updated on developments, regulations, and innovations. The platform is committed to delivering high-quality content that is relevant and impactful, making it an essential tool for professionals striving for excellence in their fields.