MOBILion Systems Unveils Groundbreaking Proteomics Technology at HUPO 2025 Conference

MOBILion Systems Set to Revolutionize Proteomics at HUPO 2025

MOBILion Systems, Inc., a pioneer in separation science, will be presenting its groundbreaking advances in proteomics at the upcoming HUPO (Human Proteome Organization) 2025 global congress, scheduled for November 9-13 in Toronto, Canada. Under the leadership of Chief Technical Officer Daniel DeBord, the company will unveil findings related to their innovative Parallel Accumulation Mobility Aligned Fragmentation (PAMAF™) technology.

PAMAF is designed to significantly enhance mass spectrometry sensitivity and throughput, which are vital for advancing proteomic and multi-omic research. In recent years, the focus of proteomic research has shifted towards post-translational modifications and proteoforms, which serve as critical indicators in drug development and clinical diagnostics.

The PAMAF technology allows for nearly 100 percent ion utilization and achieves spectral generation rates exceeding 500 Hz. These impressive performance metrics are made possible through MOBILion's high-speed High-Resolution Ion Mobility (HRIM) separation technology, which reduces dependency on traditional quadrupole filtering that often leads to signal loss.

Melissa Sherman, Ph.D., CEO of MOBILion Systems, remarked, "In a field where incremental gains can be considered significant, PAMAF delivers improvements ranging from 300 to 2,000 percent in fragment ion intensity, leading to higher identification rates of proteins and their modifications. This advancement opens the doors for researchers to identify thousands of additional proteins and post-translational modifications from smaller sample sizes, thus propelling new frontiers in proteomics, biomarker discovery, and therapeutic development."

During his presentation, DeBord will share data derived from experiments that combined MOBILion's module MOBIE® HRIM with an existing QTOF (Quadrupole Time-of-Flight) platform. The results illustrate a 100-fold increase in fragment ion intensity, with three to twelve times more protein groups identified and a 43 to 53 percent increase in the number of peptides per protein, especially benefiting low-abundance samples. The PAMAF mode is anticipated to be transformative for single-cell proteomics and quantitative measurements of post-translational modifications.

DeBord explained, "These findings highlight that improving ion utilization is a fundamental performance lever in mass spectrometry. By eliminating quadrupole filtering and aligning fragmentation with ion mobility, PAMAF enables a more comprehensive and unbiased analysis of complex biological samples, taking us closer to achieving complete proteome and proteoform coverage."

MOBILion Systems, based in Chadds Ford, Pennsylvania, develops high-performance analytical instruments that reveal unprecedented molecular details by integrating Structures for Lossless Ion Manipulation (SLIM) technology with high-resolution mass spectrometry. Their proprietary HRIM technology boosts separation power, sensitivity, and throughput across proteomics, metabolomics, lipidomics, and clinical research applications. With a mission to empower scientists in accelerating discoveries, enhancing precision medicine, and improving human health by revealing the unseen, MOBILion is paving the way for the future of proteomics.

For media inquiries:
Hannah Steele
The Scott Partnership
Email: [email protected]
Phone: +44 1477 539 539

About MOBILion Systems, Inc.

MOBILion Systems is dedicated to the development of cutting-edge analytical instruments that provide novel insights into molecular details by leveraging advanced separation technology. The company aims to enhance scientific research and ultimately improve health outcomes worldwide.