3D BioLabs Reaches Major Breakthrough with 3D Printed Liver Implant Technology for Regenerative Medicine
3D BioLabs LLC has recently accomplished a groundbreaking milestone in the arena of regenerative medicine, as highlighted in their study published in the Proceedings of the National Academy of Sciences. This remarkable advancement involves the development of a 3D printed liver implant designed to address the pressing shortages of organs available for transplantation.
Led by Dr. Joseph P. Vacanti, a distinguished professor at Harvard Medical School and Mass General Hospital, the research demonstrates a breakthrough method for constructing large organs. The approach utilizes sophisticated techniques including 3D printing, computational fluid dynamics, and organ-specific cells. Notably, the study showcases effective blood flow, cell viability, and functionality within a model device, all of which are pivotal for the eventual application of a bioengineered liver replacement.
The innovative 3D printed device created by 3D BioLabs is meticulously engineered to replicate the structure of native liver tissue. This is achieved through a fractal architecture that significantly supports both vascular anastomosis and the functioning of hepatocytes. The device includes embedded portal-venous (PV) channels that facilitate continuous blood flow post-implantation and hepatobiliary (HB) channels that sustain liver cell viability.
By actively perfusing the tissue scaffolds, the design enhances the oxygen and nutrient availability, contributing to an increased density of cells. These features point towards the feasibility of the device serving as a functional substitute for liver tissue.
Dr. Vacanti expressed his enthusiasm about reaching this crucial milestone, emphasizing the importance of advancing the development of functioning 3D printed organs. He stated, "We are extremely pleased to reach this pivotal milestone in the development of functioning 3D printed organs, which furthers our mission of solving the long-standing issue of organ transplant shortages. With our recent study, we are one step closer to achieving an engineered alternative to liver transplantation, addressing critical organ shortages and helping patients in need."
The proprietary technology employed by 3D BioLabs builds on decades of pioneering research in tissue engineering that commenced with Dr. Vacanti’s initial patent granted in 1988. This achievement follows their recent successful implantations of large and complex devices in pigs for durations of up to one week.
3D BioLabs is spearheaded by a team of scientists and engineers dedicated to improving global health by creating artificial organs for individuals plagued by organ failures and other complex tissue loss issues. Their ultimate goal is to develop a cutting-edge platform technology capable of meticulously mimicking human physiology more accurately than other existing systems, which previously encountered barriers due to the intricacies of organ size and complexity.
As the demand for organ transplants continues to escalate, the work being done at 3D BioLabs could serve as a critical solution. The hope is that through the continuous refinement and development of their technology, they can contribute significantly to alleviating the organ transplant crisis, thereby enhancing the lives of countless patients worldwide. For additional information, interested parties can explore their website at 3DBioLabs.com.
Led by Dr. Joseph P. Vacanti, a distinguished professor at Harvard Medical School and Mass General Hospital, the research demonstrates a breakthrough method for constructing large organs. The approach utilizes sophisticated techniques including 3D printing, computational fluid dynamics, and organ-specific cells. Notably, the study showcases effective blood flow, cell viability, and functionality within a model device, all of which are pivotal for the eventual application of a bioengineered liver replacement.
The innovative 3D printed device created by 3D BioLabs is meticulously engineered to replicate the structure of native liver tissue. This is achieved through a fractal architecture that significantly supports both vascular anastomosis and the functioning of hepatocytes. The device includes embedded portal-venous (PV) channels that facilitate continuous blood flow post-implantation and hepatobiliary (HB) channels that sustain liver cell viability.
By actively perfusing the tissue scaffolds, the design enhances the oxygen and nutrient availability, contributing to an increased density of cells. These features point towards the feasibility of the device serving as a functional substitute for liver tissue.
Dr. Vacanti expressed his enthusiasm about reaching this crucial milestone, emphasizing the importance of advancing the development of functioning 3D printed organs. He stated, "We are extremely pleased to reach this pivotal milestone in the development of functioning 3D printed organs, which furthers our mission of solving the long-standing issue of organ transplant shortages. With our recent study, we are one step closer to achieving an engineered alternative to liver transplantation, addressing critical organ shortages and helping patients in need."
The proprietary technology employed by 3D BioLabs builds on decades of pioneering research in tissue engineering that commenced with Dr. Vacanti’s initial patent granted in 1988. This achievement follows their recent successful implantations of large and complex devices in pigs for durations of up to one week.
3D BioLabs is spearheaded by a team of scientists and engineers dedicated to improving global health by creating artificial organs for individuals plagued by organ failures and other complex tissue loss issues. Their ultimate goal is to develop a cutting-edge platform technology capable of meticulously mimicking human physiology more accurately than other existing systems, which previously encountered barriers due to the intricacies of organ size and complexity.
As the demand for organ transplants continues to escalate, the work being done at 3D BioLabs could serve as a critical solution. The hope is that through the continuous refinement and development of their technology, they can contribute significantly to alleviating the organ transplant crisis, thereby enhancing the lives of countless patients worldwide. For additional information, interested parties can explore their website at 3DBioLabs.com.
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