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Respira Therapeutics Enters Agreement with Gossamer Bio

Respira Therapeutics, Inc. has made headlines by announcing its agreement with Gossamer Bio, Inc. that may lead to Gossamer acquiring Respira. This partnership comes at a crucial time for the development of RT234, an innovative vardenafil inhalation powder positioned as the first on-demand treatment for pulmonary hypertension (PH).

Understanding the Deal

The agreement, as noted on September 25, 2025, allows Gossamer Bio an option to acquire Respira through a series of stock issuances. Initially, Gossamer will issue 2.5 million shares upon signing, followed by an additional 1.5 million shares if the acquisition option is exercised. This strategy is designed to enhance the rapid development of RT234, a therapy intended to alleviate the challenging symptoms faced by patients with both pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD).

Pioneering a New Approach to Treatment

RT234 aims to provide rapid relief for patients enduring the debilitating effects of PH. Currently, there are no approved as-needed treatments available, and existing options often fall short, leaving many patients struggling with daily activities. As Respira’s CEO, John Kollins, emphasized, collaboration with Gossamer will expedite the development of RT234, ultimately benefiting patients suffering from this condition.

The feedback from experts has been positive; they believe that merging Respira’s cutting-edge technology with Gossamer’s strong development framework for PH treatments will lead to significant advancements in patient care.

Financial Terms and Future Steps

In addition to equity shares, the agreement includes various clinical and regulatory incentives, as well as royalties on potential sales. The partnership grants Gossamer financial responsibility for collaborative development efforts over the next two years. The primary focus will be on completing crucial Chemistry, Manufacturing, and Controls (CMC) work to prepare RT234 for subsequent clinical phases.

What Makes RT234 Unique?

RT234 is notable for being the first-ever therapy that can be self-administered by patients in need, providing immediate relief from symptoms like breathlessness. This convenience is essential for those living with chronic conditions, as it greatly enhances their ability to manage their health actively. The innovative dry-powder formulation and the advanced inhaler technology embedded in RT234 underscore its potential as a game-changer in the therapeutic landscape for PH.

Clinical trials have shown promising results, with phase 2 studies revealing substantial improvements in patient outcomes, such as increased exercise capacity and reduced breathlessness. The ongoing safety and tolerability of RT234 enhance confidence in its application as a mainstream treatment option.

Insights into Gossamer Bio

Gossamer Bio is recognized for its commitment to developing therapies for pulmonary arterial hypertension and related diseases. Their existing focus on seralutinib, combined with Respira’s new and innovative developing drugs, suggests a synergistic partnership that could lead to groundbreaking advancements in the treatment of PH.

The Bigger Picture with Samsara BioCapital

Supporting Respira through this journey is Samsara BioCapital, a leading biotech investment firm focused on startups with high potential in the healthcare sector. Their extensive portfolio and experience in advancing innovative therapeutics place them in a pivotal role to guide Respira through its upcoming phases of development.

In summary, Respira Therapeutics and Gossamer Bio's partnership represents a significant step towards improving treatment options for individuals afflicted with pulmonary hypertension, providing hope for advancements that address crucial unmet needs in this medical field.