Discovering LINC01235: A Potential Breakthrough in Treating Triple-Negative Breast Cancer

A New Hope Against Triple-Negative Breast Cancer



Breast cancer remains one of the most prevalent cancers among women in the United States, with its variants ranging in severity and treatability. Among these, triple-negative breast cancer (TNBC) stands out as particularly aggressive and challenging, affecting roughly 10 to 15 percent of breast cancer cases, especially among younger women and African American females. With no effective treatment currently available, researchers are eager for breakthroughs in understanding this discouraging condition.

Recently, a team led by Professor David Spector at Cold Spring Harbor Laboratory (CSHL) made a groundbreaking discovery that could pave the way for new therapeutic approaches to TNBC. Their research, published in Molecular Cancer Research, investigates the role of a long non-coding RNA (lncRNA) known as LINC01235. This RNA, previously linked to gastric cancer, had not been well explored in the context of breast cancer.

The journey to uncover the significance of LINC01235 began when graduate student Wenbo Xu analyzed data from The Cancer Genome Atlas, a comprehensive database that includes genetic information from over 11,000 cancer patients. Persuaded by patterns indicating that the expression of LINC01235 had a correlation with the NFIB gene—known to be associated with TNBC—Xu prompted the research team to delve deeper.

Professor Spector elaborated on their investigation, admitting that little was previously understood about both NFIB and LINC01235. Delving into questions such as how LINC01235 functions within cells and what processes it influences, the team formulated a strategic approach to study its impact on cancer development.

To evaluate LINC01235's role, the researchers employed CRISPR technology to effectively

Topics Health)

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