START Center Initiates U.S. Trial for Novel Cancer Therapy mRNA-4106
On May 15, 2025, the START Center for Cancer Research, renowned as the largest network for early-phase community oncology trials, marked a vital milestone by administering the first dose of Moderna's experimental therapy, mRNA-4106. This treatment is being evaluated in a Phase 1 clinical trial aimed at patients with advanced or metastatic solid tumors. The injection was given by Dr. Amita Patnaik at START’s San Antonio facility.
Dr. Patnaik expressed enthusiasm about this innovative approach, emphasizing that mRNA technology opens up a new chapter in immunotherapy. She noted, "We are proud to provide our patients access to this innovative treatment as part of a first-in-human trial." This trial represents a significant leap towards translating scientific discoveries into genuine treatment options for patients in need.
The trial, listed under the identifier NCT06880549, intends to assess the safety and efficacy of mRNA-4106 alone and in conjunction with checkpoint inhibitors. The therapy's multivalent strategy aims to enhance treatment availability for cancer patients, moving beyond the typical one-target immunotherapy concepts that have dominated previous approaches.
Nick Slack, MBE, the Chairman and CEO of START, reiterated the organization's dedication to accelerating new cancer therapies for patients in their communities. He stated, "This milestone reflects the core of who we are at START - accelerating the next generation of cancer therapies by bringing them directly to patients in the communities where they live."
As part of its commitment to improving patient access to transformative therapies, START collaborates with forward-thinking entities like Moderna, showcasing the collective potential to innovate cancer care.
Dr. Rose Loughlin, Executive Vice President of Research at Moderna, highlighted the inclusive nature of mRNA-4106, mentioning, "We sought to design an inclusive therapy that encodes for antigens commonly shared across patients and tumor types. We are thrilled to be able to bring this medicine to trial participants."
With a legacy of over a thousand early-phase trials led by the START Center, including numerous therapies that gained regulatory approval, their approach is rooted in the vision of "Hope Through Access." Their commitment not only aims to expedite the transition from innovative research to practical treatments but also strives to ensure that patients globally receive these advancements.
The initiative signifies a broader commitment towards redefining cancer treatment standards, showing how groundbreaking research can be conducted in closer proximity to community patient populations. START's active role in this trial serves as an important revelation of how community-based research is changing the oncology landscape and making the latest therapies accessible to more patients.
In conclusion, the dosing of the first patient in this Phase 1 trial marks a hopeful step for many fighting against cancer. It paves the way for future treatments that may lead to broader, more inclusive alternatives in cancer therapy – a promising direction in the ongoing battle against this complex disease. The participation of the START Center reaffirms its position as a leader in making innovative treatments a reality for those who need them most.
Dr. Patnaik expressed enthusiasm about this innovative approach, emphasizing that mRNA technology opens up a new chapter in immunotherapy. She noted, "We are proud to provide our patients access to this innovative treatment as part of a first-in-human trial." This trial represents a significant leap towards translating scientific discoveries into genuine treatment options for patients in need.
The trial, listed under the identifier NCT06880549, intends to assess the safety and efficacy of mRNA-4106 alone and in conjunction with checkpoint inhibitors. The therapy's multivalent strategy aims to enhance treatment availability for cancer patients, moving beyond the typical one-target immunotherapy concepts that have dominated previous approaches.
Nick Slack, MBE, the Chairman and CEO of START, reiterated the organization's dedication to accelerating new cancer therapies for patients in their communities. He stated, "This milestone reflects the core of who we are at START - accelerating the next generation of cancer therapies by bringing them directly to patients in the communities where they live."
As part of its commitment to improving patient access to transformative therapies, START collaborates with forward-thinking entities like Moderna, showcasing the collective potential to innovate cancer care.
Dr. Rose Loughlin, Executive Vice President of Research at Moderna, highlighted the inclusive nature of mRNA-4106, mentioning, "We sought to design an inclusive therapy that encodes for antigens commonly shared across patients and tumor types. We are thrilled to be able to bring this medicine to trial participants."
With a legacy of over a thousand early-phase trials led by the START Center, including numerous therapies that gained regulatory approval, their approach is rooted in the vision of "Hope Through Access." Their commitment not only aims to expedite the transition from innovative research to practical treatments but also strives to ensure that patients globally receive these advancements.
The initiative signifies a broader commitment towards redefining cancer treatment standards, showing how groundbreaking research can be conducted in closer proximity to community patient populations. START's active role in this trial serves as an important revelation of how community-based research is changing the oncology landscape and making the latest therapies accessible to more patients.
In conclusion, the dosing of the first patient in this Phase 1 trial marks a hopeful step for many fighting against cancer. It paves the way for future treatments that may lead to broader, more inclusive alternatives in cancer therapy – a promising direction in the ongoing battle against this complex disease. The participation of the START Center reaffirms its position as a leader in making innovative treatments a reality for those who need them most.
Topics Health）
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