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Revolutionizing Proteomics: MOBILion Systems at HUPO 2025

MOBILion Systems, renowned for its contributions to separation science, is set to showcase pioneering developments in the field of proteomics during the upcoming HUPO World Congress, scheduled for November 9-13, 2025, in Toronto, Canada. This year's presentation will be led by MOBILion's Chief Technology Officer, Daniel DeBord, who will delve into the remarkable capabilities of the Parallel Accumulation Mobility Aligned Fragmentation technology, commonly known as PAMAF™. This innovative technique promises to significantly elevate mass spectrometry sensitivity and throughput crucial for proteomics and multi-omics research.

As the focus of proteomics research increasingly leans toward post-translational modifications (PTMs) and proteoforms—vital elements in the drug development and clinical diagnostics arenas—emerging technologies are fundamentally altering scientists' approaches to exploring biological complexity. MOBILion's PAMAF technology stands out for its impressive ability to utilize almost all ions, touting generation rates of over 500Hz. This enhancement in performance is a direct result of MOBILion's high-speed High-Resolution Ion Mobility (HRIM) separation and marks a departure from traditional, slower quadrupole filtering methods that often compromise efficiency.

Melissa Sherman, Ph.D., the CEO of MOBILion Systems, highlighted, "In a domain where even minor advancements are typically celebrated, PAMAF offers improvements ranging from 300% to 2,000% in fragment ion intensity. This translates to significantly boosted identification rates, allowing researchers to detect a larger array of proteins and PTMs from smaller sample sizes, thereby expanding the horizons of proteomics, biomarker discovery, and therapeutic development."

During the presentation, DeBord will showcase experimental data obtained by combining MOBILion's MOBIE® HRIM module with existing Quadrupole Time-of-Flight (QTOF) instruments. These findings reveal astonishingly up to a 100-fold increase in fragment ion intensity, coupled with the identification of 3 to 12 times more protein groups per analysis, and a notable increase of 43 to 53% in peptide counts per protein. These enhancements become particularly pronounced when handling low sample input, highlighting PAMAF's transformative potential for single-cell proteomics and precise PTM quantification.

DeBord further elaborated, stating, "The advancements we have discovered underscore improved ion utilization as a critical performance lever for mass spectrometry. By eliminating the need for quadrupole filtering and aligning fragmentation with ion mobility, PAMAF facilitates a more thorough and impartial analysis of complex biological samples. This advancements brings us closer than ever to achieving complete coverage of the proteome and its proteoforms."

About MOBILion Systems, Inc.

MOBILion Systems specializes in the creation of high-performance analytical instruments that unlock molecular details previously hidden from view. They achieve this by marrying Structures for Lossless Ion Manipulation (SLIM) technology with high-resolution mass spectrometry. The proprietary High-Resolution Ion Mobility (HRIM) technology is designed to enhance separation effectiveness, sensitivity, and throughput across various research applications including proteomics, metabolomics, lipidomics, and clinical studies. Driven by a mission to empower scientific discovery and advance precision medicine, MOBILion Systems aims to unveil the unseen complexities of molecular biology to improve human health.

For more information, please contact Hannah Steele at The Scott Partnership, available via email at [email protected] or by phone at +44 1477 539 539.