Understanding the Importance of Animal-Free Raw Materials in Cell and Gene Therapy Production

Ensuring Compliance with Animal-Free Raw Materials in Cell and Gene Therapy

The landscape of cell and gene therapies (CGT) is evolving rapidly, driven by advancements in science and technology. As these therapies aim to treat and potentially cure complex diseases, the demand for high-quality materials in their production has never been more crucial. A significant component of this production process involves adhering to stringent regulatory requirements that mandate the use of animal-free raw materials.

The Webinar Overview

On November 20, 2025, Xtalks will host a pivotal online event titled "Ensuring compliance with animal-free raw materials in CGT." This free-to-attend webinar will illuminate the critical function of animal-free materials in the manufacturing of cell and gene therapies, focusing on their necessity for regulatory compliance as well as the maintenance of patient safety and product consistency.

Attendees will gain valuable insights from industry experts, including Sara Bursomanno, PhD, Senior Global Product Manager, and Chantale Julien, Global Product Manager from Novo Nordisk Pharmatech A/S. The speakers will provide in-depth discussions on validated animal-free solutions that enhance the performance of therapeutic manufacturing.

Key Discussion Points

Importance of Recombinant Insulin

Recombinant insulin has emerged as a pivotal element in cell therapy manufacturing. It not only supports cell proliferation but also plays a vital role in the production of chemically-defined media formulations. This is especially evident in its contribution to enhancing viral vector production for gene therapy applications. The use of insulin has shown to improve AAV titer and viral encapsidation significantly in HEK 293 cells, making it an invaluable resource in manufacturing processes.

The Role of Recombinant Trypsin

Another essential aspect discussed will be recombinant trypsin, which overcomes the contamination risks associated with animal-derived trypsin. By ensuring consistent enzymatic activity, it facilitates the maintenance of excellent cell viability and crucial surface markers during passaging procedures. This makes recombinant trypsin a preferred solution in cell therapy workflows where maintaining cell quality is paramount.

Real-World Applications and Challenges

A recent study highlighted during the webinar evaluated the effectiveness of both recombinant insulin and recombinant trypsin in mesenchymal stem cell cultures. This research demonstrated that insulin stimulates cell proliferation while trypsin maintains cell viability and phenotype during dissociation. These findings illustrate how both materials can collectively fulfill the rigorous performance standards required for therapeutic manufacturing.

While many manufacturers encounter challenges in sourcing reliable, compliant materials that perform optimally, this webinar aims to tackle these issues head-on. By exploring validated solutions, attendees will learn how to meet regulatory expectations while sustaining high manufacturing performance using animal-free materials.

Register for the Webinar

For those interested in the intricate relationship between animal-free raw materials and CGT manufacturing, this webinar presents an excellent opportunity to learn from industry leaders. Participants can expect to walk away with actionable insights that enhance their understanding of how to integrate these materials into their processes effectively.

Join us on November 20, 2025, at 10 AM EST (4 PM CET). For further details on the event and registration, please visit the Xtalks website.

Xtalks, powered by Honeycomb Worldwide Inc., has established itself as a leading provider of educational webinars tailored for professionals in the life sciences, food, healthcare, and medical device sectors. This platform not only aids in keeping industry practitioners informed but also fosters discussions on crucial topics affecting the CGT landscape.

By attending this informative session, participants will be better equipped to navigate the complexities of regulatory compliance in CGT production and embrace the shift towards animal-free materials in therapeutic manufacturing processes.

Don't miss out on this chance to enhance your knowledge in the field of cell and gene therapies—register today!

For more information about hosting your own webinar or to discover other sessions hosted by Xtalks, please visit their website.