#USA #Atlanta #Stellaromics #Pyxa #Emory University

Stellaromics Expands Its Research Horizons with Pyxa™ Installation at Emory University

Stellaromics, renowned for its cutting-edge advancements in 3D spatial biology, has made a significant stride by introducing its innovative Pyxa™ 3D spatial multi-omics system at Emory University School of Medicine. With this installation, Emory joins the ranks of the University of Glasgow and the University of California, Irvine as the third beta testing site for this revolutionary technology.

The Pyxa™ system has found its new home in the lab of Dr. Hailing Shi, who is an assistant professor in the Department of Human Genetics at Emory. Dr. Shi's research focuses on the intricate mechanisms of RNA regulation as they pertain to brain function and the progression of neurodegenerative diseases. Her lab is committed to uncovering context-dependent RNA regulation principles, and the Pyxa™ system will significantly enhance their capabilities in this specialized field.

By integrating elements of nucleic acid chemistry, spatial genomics, and computational analysis, the Shi laboratory aims to delve into the spatial organization of the central nervous system with remarkable precision. This includes examining how RNA regulation and modifications operate within a three-dimensional tissue context, a critical factor in understanding neurodegenerative disorders.

Dr. Shi expressed enthusiasm about the new technology, stating, "The architecture of the brain is inherently three-dimensional, and understanding its function requires tools that can capture that complexity without compromising resolution. Having witnessed the evolution of STARmap methods, I appreciate both the scientific power of 3D spatial transcriptomics and the challenges faced in making these approaches practical for everyday research. It is truly exciting to see Pyxa mature into a commercial-grade system that allows us to visualize cellular neighborhoods and RNA dynamics more effectively."

The Pyxa™ system stands out for its ability to deliver high-resolution multiplexed 3D spatial transcriptomics within tissue sections up to 100 µm thick. This feature ensures that the native architecture and spatial context of the tissue are preserved across various cellular layers. Furthermore, Pyxa™ can capture subcellular details for numerous molecular targets simultaneously, thus enabling researchers to piece together complex interactions within tissues—an essential endeavor for studying biological processes in both health and disease.

Todd Dickinson, CEO of Stellaromics, welcomed Dr. Shi and Emory University to the beta program, highlighting her extensive expertise in spatial technology and her commitment to unraveling the complex molecular landscapes of the brain. He emphasized how her work could redefine the limits of what is achievable in 3D spatial biology, asserting that collaborations like these not only validate the potential of Pyxa™ but also foster breakthroughs in human genetics and neuroscience.

The installation of the Pyxa™ system at Emory University marks a promising chapter in advancing research methodologies within the realms of molecular biology and neuroscience. As the search for answers to complex questions surrounding gene expression and disease progresses, technology like Pyxa™ will undoubtedly play a pivotal role in shaping the future of biomedical research.

Stellaromics, headquartered in Boston, Massachusetts, is dedicated to pioneering breakthroughs in 3D spatial multi-omics. With the introduction of their Pyxa™ system in various prestigious research institutions, they continue to empower researchers with advanced tools to explore biological complexities that could lead to significant health improvements.

For additional inquiries, media contacts include Kristen White, Co-Founder and Partner at Oak Street Communications, reachable at 415.608.6060 or via email.