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Clarifying Glutathione Misunderstandings

As the health and wellness industry continues to highlight the significance of glutathione, various misconceptions about the substance arise. Kyowa Hakko Bio, the creator of the renowned Setria® Glutathione, has taken the initiative to clear the air, focusing on the product's quality standards and its proven efficacy. This master antioxidant is making headlines as it becomes increasingly recognized for its roles in cellular defense, detoxification, and immune support.

The Setria® Advantage

Launched nearly two decades ago, the Setria® brand has stood as a beacon of verified quality in a market where glutathione products vary greatly in purity and efficacy. Particularly in today's landscape, consumers are confronted with varying product standards, leading to questions about what truly constitutes an effective supplement. According to data from the National Health and Nutrition Examination Survey (NHANES), a significant portion of the population suffers from glutathione deficiency, likely due to modern eating habits that lack adequate glutathione-rich foods. This underscores the importance of relying on high-quality supplements like Setria® to fill that gap and enhance overall health.

Katie Emerson, MS, RD, the Senior Manager of Scientific Affairs at Kyowa Hakko USA, emphasized that the critical question isn't about the importance of glutathione, but whether oral supplements can deliver tangible benefits. Recent studies, including one from Richie et al., are revealing that orally administered glutathione can indeed be absorbed into systemic circulation, effectively addressing skepticism regarding its bioavailability.

Clinical Backing and Real Benefits

What sets Setria® apart is its robust clinical validation. A comprehensive six-month study conducted at Penn State University, published in the European Journal of Nutrition, demonstrated that daily doses of 250 mg and 1,000 mg of Setria® lead to boosts in glutathione levels—30-35% in blood cells and an impressive 260% in buccal cells. Beyond elevating glutathione levels, the study revealed functional improvements, such as a doubling of natural killer cell activity, showcasing enhanced immune function.

Moreover, Setria® Glutathione offers additional benefits beyond basic antioxidant functions. Research indicates it supports skin health, evidenced by a 12-week study that confirmed a reduction in melanin levels when individuals incorporated Setria® into their routine. In the realm of sports nutrition, combining Setria® with L-citrulline has been shown to elevate nitric oxide levels, which supports athletic performance as detailed in the Journal of Exercise and Nutrition.

A Commitment to Quality

Setria® is manufactured through a proprietary fermentation process that adheres to high purity and quality standards, including USP standards and GMP compliance. With the growing presence of low-cost alternatives that compromise quality, ensuring that consumers receive a safe and effective product is paramount. Emerson reiterated that while dietary changes and healthy lifestyle choices are primary, supplementation can provide valuable assistance for those with diminishing glutathione levels due to factors like aging or stress.

“Supplementation serves to complement, not substitute, basic health practices,” Emerson shared. The data supporting Setria® has made it a trusted ingredient across several regions, including the United States, Canada, and across Europe and South America, helping brands align their products with reliable standards and facilitating international growth.

Interestingly, in Brazil, Setria® stands out as the only glutathione source approved by ANVISA, the Brazilian Health Regulatory Agency, signifying its acceptance in stringent markets.

As regulations tighten within the health supplement space, it is imperative for businesses to prioritize substantiated product claims. Kyowa Hakko remains a proponent for informed consumer choices regarding glutathione supplementation, aiming to build trust in its potential benefits for immunity, skin, and overall health as people age.

About Setria and Kyowa Hakko

Setria® Glutathione, developed by Kyowa Hakko Bio Co., Ltd., is a clinically validated and patented form of glutathione shown to replenish the body's dwindling reserves due to lifestyle factors and natural aging. Recognized as the “master antioxidant,” glutathione acts as a shield for cells against oxidative stress and toxins. The manufacturing process behind Setria® ensures high purity and quality, keeping it non-GMO, vegetarian, and allergen-free. For further details on this premier ingredient, visit SetriaGlutathione.com.

Kyowa Hakko USA serves as the North and South American branch of Kyowa Hakko Bio, a global leader in health ingredients, pharmaceuticals, and nutraceuticals. As the maker of renowned ingredients including Cognizin® and Eyemuse®, Kyowa is committed to transparency and quality, fostering trust in health products. To learn more about their innovation-driven initiatives, visit kyowa-usa.com.