#United States #San Diego #presbyopia #LENZ Therapeutics #VIZZ

LENZ Therapeutics Launches VIZZ for Presbyopia

LENZ Therapeutics is excited to announce the launch of its groundbreaking product, VIZZ (aceclidine ophthalmic solution), designed specifically for adults struggling with presbyopia. This new treatment promises to enhance near vision for those affected by age-related vision loss, a condition that impacts around 128 million adults in the United States alone.

Launch Details

As of October 2025, VIZZ will be commercially available, following a successful nationwide distribution of product samples to eye care professionals (ECPs). This strategic rollout enables optometrists and ophthalmologists to become familiar with VIZZ before consumer shipments commence later this month. By midway through the fourth quarter of 2025, this innovative eye drop is expected to reach retail pharmacies across the nation, making it widely accessible to those in need.

Innovative Mechanism

VIZZ stands out as the first and only eye drop that utilizes aceclidine to treat presbyopia, a common condition typically beginning in individuals over 45 years old. Unlike other treatments, VIZZ works primarily by contracting the iris sphincter muscle, creating a pinhole effect that enhances depth of focus. This unique mechanism allows patients to enjoy clear near vision for up to 10 hours, providing relief and restoring confidence for those who may struggle with reading text up close without corrective glasses.

In the CLARITY Phase 3 clinical trial, a remarkable 93% of participants achieved visual acuity of 20/40 or better within just 30 minutes of application. The majority maintained this enhanced vision for several hours, showcasing the product's effectiveness in real-world scenarios.

Positive Reception

Eef Schimmelpennink, President and Chief Executive Officer of LENZ Therapeutics, expressed his enthusiasm for the product's introduction: "We are thrilled to bring VIZZ to the 128 million adults living with blurry near vision. The feedback from the ECP community has been overwhelmingly positive, and we feel confident that VIZZ will redefine how presbyopia is treated."

Shawn Olsson, Chief Commercial Officer, added, "VIZZ provides a fast-acting solution for millions seeking freedom from reading glasses. Whether it's reading a text message or checking a price tag, VIZZ aims to improve daily life for those with presbyopia."

Understanding Presbyopia

Presbyopia is a natural aging process that affects everyone, typically making itself known in the mid-40s as the crystalline lens in the eyes gradually hardens and loses elasticity. This loss impairs the eye's ability to focus on close objects, resulting in frustration and inconvenience for individuals who now require reading glasses or other aids. While many self-manage the condition with over-the-counter solutions, the introduction of VIZZ promises a more effective, long-lasting alternative.

Safety and Administration

VIZZ is formulated as a once-daily, preservative-free eye drop, available in single-dose vials. However, it is crucial to follow certain precautions:

• - Avoid contact between the vial tip and any surface, including the eye, to prevent contamination.
• - Do not use if allergic to any ingredients listed.
• - If using other topical eye medications, ensure a 5-minute interval between applications.

Temporary dim or dark vision may occur post-application, necessitating caution while driving or operating machinery until clarity returns.

For more comprehensive details on VIZZ, including prescribing information, consumers are encouraged to visit www.VIZZ.com.

About LENZ Therapeutics

LENZ Therapeutics is at the forefront of pharmaceutical innovation, dedicated to improving lives through cutting-edge treatments like VIZZ. Headquartered in San Diego, California, LENZ aims to leverage partnerships for further expanding access to this essential therapy globally, ultimately seeking to address the needs of the 1.8 billion people worldwide suffering from presbyopia. Through diligent effort and partnerships, LENZ is committed to making a substantial impact in the vision care landscape.