#Japan #Tokyo #Hasegawa Fragrance #NANOLYS #IFSCC Congress

Breakthrough in Liposomal Technology for Sensitive Skin

In a notable advancement within the cosmetic science field, Hasegawa Fragrance Co., Ltd., headquartered in Chuo-ku, Tokyo, presented groundbreaking findings at the IFSCC Congress 2025 held in Cannes from September 15 to 18. Their research showcased that liposomes formulated with acidic phospholipids significantly enhance the skin's barrier functions compared to traditional neutral phospholipid formulations.

This innovative study was conducted in collaboration with Nikkol Chemicals Co., Ltd., a company renowned for its expertise in personal care, pharmaceuticals, and chemical ingredients, since its founding in 1946. The research aimed to delve deeper into how liposomal technology can be optimized for sensitive skin while also providing substantial support for the customer base through open laboratories and information dissemination.

Significance of the IFSCC Congress

The International Federation of Societies of Cosmetic Chemists (IFSCC) is a highly respected organization, acting as the upper body of the Japan Society of Cosmetic Chemists (SCCJ). Each year, it organizes a congress that attracts cosmetic development professionals from around the globe. At the 2025 Cannes event, a total of 798 research reports were presented, which included 68 oral presentations and 730 poster presentations, with rigorous selection criteria for participants showcasing their work.

Key Presentation by Hasegawa Fragrance

The title of the presentation was "A Breakthrough in Liposomal Technology: Enhanced Stability and Skin Barrier Function of Liposomes Through the Utilization of Acidic Phospholipids." The team from Hasegawa included Yuya Ueda, Takao Ochi, and Takahiro Sakai, alongside Nikkol's Takushi Minori and Masato Yukue.

Their research concentrated on the much-anticipated application of acidic phospholipids (AP) in the creation of more effective liposomes. Traditionally, studies surrounding liposomes have focused largely on their permeability; however, there were fewer reports regarding their effects on skin improvement.

Hasegawa Fragrance's research determined that the incorporation of AP into liposomal formulations, replacing a portion of phosphatidylcholine (PC), achieved superior stability. Notably, they identified that liposomes containing approximately 50% AP not only strengthened tight junctions but also significantly increased the expression of Claudin-1, a critical protein for skin barrier integrity, establishing a new standard in liposomal formulation.

Future Directions in Liposomal Research

The innovative acidic phospholipid technology introduced by Hasegawa is integrated into their original ingredient, NANOLYSⓇ. Their commitment to providing groundbreaking nano-solution products for sensitive skin is evident, and they intend to enhance and deepen liposomal technology for the foreseeable future.

For more information regarding NANOLYSⓇ and its applications, please visit the Hasegawa website. The advancements made by Hasegawa Fragrance not only signify an important milestone in cosmetic technology but also pave the way for tailored solutions for individuals with sensitive skin concerns.

As the understanding of lipid-based delivery systems evolves, the integration of acidic phospholipids presents an exciting frontier in skincare, particularly for those with susceptibility to skin irritation. Hasegawa Fragrance, alongside its partners, is set to continue pushing the boundaries of innovation in this space, ensuring that sensitive skin receives the care it deserves.