#Japan #Osaka #Drug Crystallization #Pharmaceutical Science #Crystallization Techniques

Introduction

In the ever-evolving field of pharmaceuticals, understanding the crystallization and stability of drugs is crucial. A newly released edition of a practical guide provides extensive insights into drug crystallization techniques and evaluation methods.

About the Publication

The book, edited by Wataru Kawakami, officially hits the shelves on May 8, 2025, and serves as a widely available version of a previously published work. It comprises 261 pages in B5 format and is priced at 5,280 yen (tax included). This edition comes at a lower cost, making it more accessible to practitioners in the field.

Essential Details

• - ISBN: 978-4-7813-1829-5
• - Availability: Orders can be placed through our EC site or at bookstores nationwide. The electronic version is also available for purchase on the dedicated CMCeBook site.

Author Contributions

The publication features contributions from a diverse group of authors, including notable researchers from various institutions. These experts bring their knowledge and expertise in crystallization and drug development:

• - Wataru Kawakami (National Institute for Materials Science)
• - Mihoko Maruyama (Osaka University)
• - Masashi Yoshimura (Osaka University)
• - Kazufumi Takano (Kyoto Prefectural University)
• - Yusuke Mori (Osaka University, SoShin Co., Ltd.)
• - Hiroshi Takiyama (Tokyo University of Agriculture and Technology)
• - Hidehiro Uekusa (Tokyo Institute of Technology)
• - Masatoshi Karashima (Takeda Pharmaceutical Company Limited)
• - Kyoko Kitakuse (Shionogi Pharmaceutical Co., Ltd.)
• - Tomonori Oikawa (Sawai Pharmaceutical Co., Ltd.)
• - Keita Nakanishi (Astellas Pharma Inc.)
• - A total of 24 authors contributed to this comprehensive resource.

Table of Contents

The book is structured into five detailed parts that cover a wide range of topics:

Part 1: Creation of Pharmaceutical Crystals

• - Chapter 1: Techniques for Crystallizing Pharmaceutical Compounds
• - Chapter 2: Quality Control of Co-crystals
• - Chapter 3: Powder Crystal Structure Analysis of Pharmaceutical Crystals
• - Chapter 4: Development Form Studies of APIs

Part 2: Practical and Cutting-edge Property Evaluation

• - Chapter 5: Property Parameters in Drug Discovery Phases
• - Chapter 6: API Property Evaluation Using New Dissolution Property Evaluation Equipment
• - Chapter 7: Necessity of Property Evaluation in Drug Delivery Systems (DDS)
• - Chapter 8: Practical Aspects of Solubility Measurement
• - Chapter 9: Practical Aspects of Particle Size Measurement

Part 3: Evaluation of Crystals

• - Chapter 10: In Silico Technology for Polymorphic and Property Predictions
• - Chapter 11: Crystal Form Evaluation via Low-Frequency Raman Spectroscopy
• - Chapter 12: Crystallization and Formulation of Hygroscopic Active Pharmaceutical Ingredients (APIs)
• - Chapter 13: Polymorphic Transitions and Evaluations in Formulation Processes

Part 4: Control and Evaluation of Amorphous Substances

• - Chapter 14: Crystallization Trends of APIs
• - Chapter 15: Secondary Nucleation in Crystallization
• - Chapter 16: Structural Analysis Using Pair Distribution Functions: Applications in Pharmaceuticals
• - Chapter 17: Utilizing Over-Saturation Potential of Amorphous Pharmaceutical Design

Part 5: Development Techniques for Biopharmaceuticals

• - Chapter 18: Development of Plates for Promoting Protein Crystallization Using Plasmon Resonance
• - Chapter 19: Fundamental Property Evaluation of Antibody Pharmaceuticals
• - Chapter 20: Analysis of Protein Aggregates

Conclusion

This essential publication is a must-have for professionals involved in pharmaceutical science, providing a detailed understanding of various crystallization techniques and evaluations. Whether one is involved in academia or industry, this guide will enhance their expertise and contribute to advancements in drug development.