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World Precision Instruments Launches EVOM™ Auto ElectroZ

World Precision Instruments (WPI), a company renowned for its precision instruments in life science research, has recently unveiled its latest product: the EVOM™ Auto ElectroZ. This innovative instrument enhances the previously established platform for measuring transepithelial/endothelial electrical resistance (TEER) by incorporating advanced electrochemical impedance spectroscopy (EIS) capabilities.

For years, researchers have utilized TEER to evaluate cellular barrier integrity by assessing the electrical resistance across cell layers. The launch of EVOM™ Auto ElectroZ marks a significant leap forward, providing a wealth of data regarding cellular growth, maturation, morphology, and polarization—all without changing the workflow or models currently in use.

Enhancing TEER with EIS Technology

As explained by Mark Rutledge, the CEO of WPI, the conventional TEER method, while essential for understanding cellular barrier function, does not capture the full spectrum of cellular behavior. The ElectroZ feature enables researchers to go beyond basic resistance measurements, utilizing various frequencies ranging from 2 Hz to 100 kHz. This broader frequency range captures both resistive and capacitive properties, offering a more detailed glimpse into cell characteristics than ever before.

The advantages of this technology are particularly pronounced in the context of research involving physiologically relevant tissue barriers. Where traditional TEER methods often necessitate separate blank measurements and manual adjustments, the ElectroZ can calculate key parameters, such as TEER since it can differentiate the cellular resistance from the contributions of the media and matrix proteins, streamlining the research process significantly.

Key Features of EVOM™ Auto ElectroZ

1. Multi-Frequency Measurements: The instrument provides a rich dataset through a quick, typically less than 20-second measurement process. This includes:
- TEER Cellular Resistance: Separating resistance attributed to the cell layer from other factors.
- TEER Total: Assessing total resistance, factoring in background contributions.
- Transepithelial Capacitance (TEC): Analyzing key aspects of cell growth and health.
- Tau Ratio: A new parameter that investigates cellular polarity at a deeper level.

2. Compatibility with Commercial Transwell Plates: Unlike older impedance systems that require specialized electrodes, the ElectroZ uses interchangeable electrode arrays within established transwell formats, crucial for studies on various physiological barriers including the blood-brain barrier and airway epithelium.

3. Non-Destructive Measurements: Researchers can repeatedly characterize living cultures while preserving them for further analyses such as permeability testing, imaging, and immunocytochemistry.

4. Simplicity of Use: It combines the straightforward operation of traditional TEER with the advanced measurement capabilities of EIS, allowing researchers to dive deeper into cellular analysis without needing complex equipment setups.

Conclusion: A New Era for Cellular Research

The introduction of the EVOM™ Auto ElectroZ represents a transformative step in cell-based research, bridging the gap between traditional TEER assessments and advanced impedance analysis. This new platform opens the door for researchers to conduct more comprehensive cellular analyses without the cumbersome need for different instruments, thus ensuring efficient research processes.

As noted by Rutledge, “It's about making advanced cellular analysis more accessible while preserving the biological relevance of the model and experiment.” With it, WPI aims to support advances in drug discovery, disease modeling, and tissue engineering.

For further details about the EVOM™ Auto ElectroZ and to elevate your research capabilities, visit wpiinc.com/eis.

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About WPI: World Precision Instruments has pioneered precision instruments and lab equipment for nearly six decades, empowering researchers worldwide in fields like neuroscience, cell biology, and physiology. They are committed to enhancing experimental outcomes with innovative tools tailored for life sciences.