ASUS Unveils Advanced AI Infrastructure with NVIDIA GB300 NVL72 at SC25 Event

On November 18, 2025, ASUS showcased its impressive AI infrastructure portfolio at the Supercomputing 2025 event, held in St. Louis. Centered on the NVIDIA Blackwell architecture, the company aimed to promote 'Ubiquitous AI. Incredible Possibilities.' This initiative is about enhancing computing capabilities for businesses, pushing them towards quicker go-to-market strategies with unparalleled performance.

Key Highlights of the New AI Infrastructure

Among the standout products was the ASUS XA GB721-E2, a powerful AI pod that leverages the NVIDIA GB300 NVL72. This robust system features 72 NVIDIA Blackwell Ultra GPUs coupled with 36 NVIDIA Grace CPUs, embodying a sophisticated rack-scale architecture. With its complete liquid cooling system and integrated switches, the XA GB721-E2 is designed for scalability, delivering a commendable 10 petaflops of computing power ideal for enterprise AI and cloud workloads.

Further exemplifying ASUS' capability in AI solutions, the ESC NM2N721-E1 was unveiled, showcasing advancements in sovereign AI deployment. Designed to support national-scale AI initiatives, this platform integrates storage and compute resources seamlessly. Another significant introduction was the ASUS ESC8000A-E13X — a 4U NVIDIA RTX PRO Server tailored for enterprise AI workloads, featuring a compact design powered by dual AMD EPYC 9005 processors and accelerated by eight NVIDIA RTX PRO GPUs. This system emphasizes efficient large-model AI training and inference with high-density performance.

Broadening the Ecosystem

ASUS's commitment to AI solutions extends to various applications ranging from expansive data centers to personal devices. The XA NB3I-E12, based on the NVIDIA HGX B300 system, boasts high performance and cooling efficiency tailored for demanding AI training workloads. Supporting large-model training and multi-GPU setups via NVIDIA NVLink, it is poised to enhance organizational AI development processes.

Additionally, the ESC NB8-E11, featuring the NVIDIA HGX B200 system, is designed for inference and AI applications, providing essential computing density and flexibility for edge and production environments.

For creators and developers, the ExpertCenter Pro ET900N G3 supercomputer is equipped with the NVIDIA Grace Blackwell Ultra Superchip, making AI computing accessible for professionals. Meanwhile, the compact ASUS Ascent GX10 personal AI supercomputer offers advanced AI exploration in a user-friendly desktop form.

Professional Services for Seamless Integration

To further enhance its offerings, ASUS has built a robust ecosystem of partners to provide comprehensive support throughout the data center lifecycle, from design and implementation to management. At SC25, ASUS announced a partnership with Vertiv, leveraging their extensive power and cooling solutions to optimize the NVIDIA GB300 NVL72 platforms. This collaboration aims to enhance energy efficiency and facilitate industrial-scale AI deployments by improving thermal management and power integration.

As ASUS combines NVIDIA’s Blackwell and Blackwell Ultra architectures with sophisticated cooling, storage solutions, and expert integration, it continues evolving AI and supercomputing infrastructures. Through its professional services, ASUS assures clients of reliable engineering support, validation, and deployment solutions, streamlining management across multi-node and multi-rack clusters.

For an immersive experience into AI infrastructure, attendees are invited to visit ASUS at Booth #3732.

Conclusion

ASUS has decisively positioned itself as a leader in AI infrastructure, emphasizing its capabilities in providing complete solutions for various AI needs. By integrating cutting-edge technologies, it is set to democratize access to powerful AI tools for users across all sectors. For further details and inquiries, attendees and interested clients can reach out to their local ASUS representative directly.