Exploring the Future of Japanese Sake: Symposium on Longevity and Fermentation

Tsunan Brewery Takes Center Stage at Longevity and Sake Symposium

On August 8, 2025, Tsunan Brewery, located in the Niigata Prefecture of Japan, participated in a symposium titled "The Potential of Japanese Sake and Longevity" held at the Takanawa Gateway Link Scholars’ Hub. Organized by Regenesome Co., Ltd., this event brought together researchers, industry professionals, and media to explore innovative synergies between fermentation and longevity.

Event Highlights

At the symposium, critical insights into the latest trends linking fermentation processes to health and longevity were shared. Tsunan Brewery showcased practical implementations of sake upcycling and shared their collaborative research on Japanese sake-derived nanoparticles known as SAKESOME. Guests were treated to tastings of their pure rice Daiginjo sake, “GO TERRACE,” as a welcome drink, allowing them to experience the flavor profile that highlights the brewery's craftsmanship.

Scientific Background

As aging leads to increased oxidative stress, cellular senescence, and decreased tissue homeostasis, the health span of individuals is significantly affected. Components derived from fermentation, such as ergothioneine, agmatine, and alpha-EG, along with the sake-derived nanoparticles SAKESOME, have demonstrated potential antioxidant and blood vessel-dilating properties, suggesting they could positively influence intercellular communication.

At the event, Tsunan Brewery shared their philosophy on harnessing traditional sake brewing techniques while integrating cutting-edge biotechnological advancements to explore new possibilities within the sake industry. This initiative emphasizes the highly valuable use of sake lees, addressing sustainability while enhancing product offerings.

Keynotes by Watanabe Inari

One of the notable speakers was Watanabe Inari from SSI Sake Academy, who spoke about the evolving market landscape. While domestic consumption of sake matures, overseas demand is on the rise, focusing on lower alcohol content and functional implications that cater to a sustainable experience.

As sake transcends traditional boundaries, the synergy of culture and innovation is catalyzed through UNESCO recognition, further enhancing global interest.

Watanabe also delved into the scientific manufacturing processes of sake, describing how rice, koji, and water are combined through parallel multiple fermentation—a hallmark feature of sake production.

He provided examples of upcycled craft saké made from hop byproducts, affirming the industry's commitment to reducing food waste while creating new sensory experiences.

Projects and Experiences at Tsunan Brewery

Tsunan Brewery highlighted their sake upcycling project, which focuses on transforming sake lees and byproducts into food and materials. This approach emphasizes regional circulation and combines art, science, and craft design. From a consumer perspective, the brewery aims to enhance both flavor and functionality through collaborative research on their sake-derived nanoparticles, SAKESOME.

In addition, attendees enjoyed a tasting of GO TERRACE, their terroir-based sake, showcasing the exquisite flavors sourced from the area's renowned Koshihikari rice. The subtle sweetness of the rice complemented the clean, crisp taste reminiscent of meltwater from the snowy regions where the rice is cultivated.

Symposium Details

The event was structured as follows:

- Theme: The Potential of Japanese Sake and Longevity
- Date: August 8, 2025 (Friday)
- Time: 18:00 - 19:00 (Doors open at 17:45)
- Location: LiSH Studio 1, Tokyo
- Audience: Industry professionals, researchers, media personnel

The program included an introduction and tasting of GO TERRACE, followed by presentations from Watanabe Inari and Tsunan Brewery representatives, concluding with a Q&A session.

About Regenesome Co., Ltd.

Regenesome focuses on new solutions for aging suppression and regenerative medicine through the use of nanoparticles like exosomes. Their research dives into the cellular mechanics that guide these nanoparticles, aiming to develop medical technologies that extend health spans while exploring potential applications in space medicine.

About Tsunan Brewery

Tsunan Brewery, located in Niigata, is renowned for its premium sake, utilizing water sourced from the snow-capped mountains. They balance traditional techniques with innovation, having recently won the Niigata Governor's Prize at the Echi Flow Sake Brewing Technology Competition. Their philosophy is encapsulated in their brand concept, "Brew for Future - Cultivating a Coexistent Future."
Check out their products here.

For further insights and future updates, stay tuned for more events showcasing the exquisite world of Japanese sake and its potential impact on longevity.