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Revolutionizing DNA Library Preparation with Callisto™ Complete Kit

At the recent Advances in Genome Biology and Technology (AGBT) General Meeting 2026 in Orlando, Florida, Volta Labs, a leader in sample preparation automation for Next-Generation Sequencing (NGS), unveiled its groundbreaking Callisto™ Complete Kit for DNA EF library preparation. This innovative solution merges the industry-leading NGS preparation capabilities from Watchmaker Genomics with Volta’s advanced digital fluidics automation, facilitating a fully automated and PCR-free workflow for preparing libraries for whole-genome sequencing (WGS).

As whole-genome sequencing gains traction in clinical and translational research environments, the demand for PCR-free workflows is increasing. These workflows help minimize amplification bias, reduce sequencing artifacts, and ensure more uniform genome coverage, especially in GC-rich regions. However, executing PCR-free library preparation requires precision and reproducibility, making automation essential for laboratories seeking consistent results without overloading their staff.

The Callisto™ Complete Kit transforms the library preparation process by eliminating manual liquid handling and reducing operator variability. This allows laboratories to produce reproducible, high-quality libraries while freeing up technical staff to concentrate on higher-value tasks. Udayan Umapathi, CEO of Volta Labs, emphasized that the Callisto was designed to make sequencing sample preparation simpler and more accessible. With this kit, laboratories can conduct PCR-free workflows for whole-genome sequencing at the push of a button, delivering consistent, high-quality results ideal for mid-throughput settings.

In support of this launch, Volta Labs and Watchmaker Genomics will co-host a presentation on February 24 at 8:30 AM in the Fulton Suite at AGBT 2026. Attendees will learn more about the Callisto™ Complete Kit for DNA EF library preparation and see the automated PCR-free WGS workflow in action. Both teams will share insights about maximizing laboratory efficiency with this innovative technology.

About Volta Labs

Volta Labs is spearheading a new era in sample preparation for sequencing through a unique platform that integrates digital fluidics, modular workflows, and complete walk-away automation. The Callisto™ platform provides high-quality, reproducible NGS library preparation tailored for whole-genome, targeted, and custom applications, ensuring a seamless experience for research teams. Headquartered in Boston, Massachusetts, Volta Labs continues to push the boundaries of innovation in the genomics space.

About Watchmaker Genomics

Watchmaker Genomics is at the forefront of life sciences, focusing on the development of powerful tools for genomic research and clinical applications. Leveraging expertise in protein engineering and NGS, Watchmaker provides precise reagents and platforms that ensure outstanding accuracy, efficiency, and cost-effectiveness in molecular analysis. Committed to advancing breakthrough technologies, the company supports innovations in cancer detection, epigenetics, and liquid biopsy applications.

For further inquiries, media representatives can contact:

• - Nicole Ellis Ovadia, Director of Strategic Marketing, Volta Labs at [email protected]
• - Jen Pavlica, Deputy Director of Product Marketing, Watchmaker Genomics at [email protected]

This new kit marks a significant advancement in the genomic sequencing realm, enabling research facilities to enhance productivity and precision with minimal effort. Stay tuned for more updates as these technologies continue to evolve.