Paradigm Health Welcomes Dr. Karen E. Knudsen as Board Member and Introduces New AI Tool for Clinical Trials

On March 20, 2025, Paradigm Health, a company dedicated to transforming the clinical research landscape, announced a significant development in its leadership and technology initiatives. The organization is thrilled to welcome Dr. Karen E. Knudsen, a distinguished leader in oncology and healthcare, to its Board of Directors. Alongside this appointment, Paradigm Health also launched its innovative eSource Casebook, an advanced solution designed to enhance clinical trial data collection and management.

A New Voice in Oncology Leadership

Dr. Knudsen brings a wealth of experience and a robust track record in cancer research and clinical operations. Previously, she served as Chief Executive Officer of the American Cancer Society (ACS) and has held significant roles including EVP of Oncology Services for Jefferson Health. Her leadership experience includes managing a National Cancer Institute-designated cancer center, which provides her with deep insights into the constraints faced by clinical trials.

Reflecting on her new role, Dr. Knudsen expressed, "Having led a National Cancer Institute-designated cancer center, I've seen how administrative burdens limit clinical trial capacity. Paradigm Health's tech-driven approach addresses one of healthcare’s fundamental challenges, helping to broaden access to trials for patients. This mission resonates with my dedication to enhancing care options for all."

Transformative Technology: eSource Casebook

In conjunction with Dr. Knudsen's appointment, Paradigm Health unveiled the eSource Casebook—a groundbreaking application within its Study Conduct solution suite. This innovative platform automates the entire process of data capture and auditing for clinical trials, addressing the inefficiencies caused by manual data entry, which often results in significant time delays and resource drain.

Traditionally, clinical trial teams have had to engage in a labor-intensive process of entering patient data multiple times, resulting in an average eight-day lag from patient visits to data entry. eSource Casebook transforms this experience by allowing clinical staff to enter data just once in the patient's electronic medical record (EMR). The system then automatically populates clinical report forms and streams information to the trial sponsor, streamlining data management and improving efficiency.

Dr. Knudsen commented, "Seeing eSource Casebook in action was a lightning bolt moment. Today's healthcare infrastructure often burdens research teams with tedious data entry tasks. Reducing this manual workload will not only save time but will also alleviate pressures on providers, thereby expanding opportunities for new research."

The Mission Forward

Kent Thoelke, CEO of Paradigm Health, highlights how the company’s focus on innovative solutions like eSource Casebook is reshaping the clinical trials landscape. "Historically, the lack of efficient data entry has limited the progression of medical research. By making the data transfer automatic and seamless, we are addressing a crucial bottleneck in clinical trials. Our use of advanced LLMs ensures data accuracy while minimizing time and cost."

With plans for a widespread rollout of eSource Casebook set for April, Paradigm Health aims to further enhance patient access to clinical trials across healthcare providers. The company's strategies focus on integrating its platform within health systems to make trials more intelligent and impactful.

In sharing her excitement about the collaboration, Dr. Knudsen emphasized that her experience in oncology and patient advocacy aligns perfectly with Paradigm's vision of equitable access to clinical trials for all patients, regardless of their geographical locations.

Through such innovative initiatives and the guidance of experienced leaders like Dr. Knudsen, Paradigm Health is poised to make significant strides in advancing the future of clinical research and improving patient outcomes.

For further information about Paradigm Health's services and the upcoming eSource Casebook release, interested organizations can reach out via Paradigm Health Contact Page.

About Paradigm Health

Paradigm Health is committed to reshaping the clinical research ecosystem by providing equitable access to clinical trials while enhancing operational efficiency. With services deployed at over 400 research sites and more than 1,000 healthcare provider locations, Paradigm Health is actively working to ensure that clinical trials are accessible and effective for patients nationwide.