#Canada #Toronto #C. glutamicum #VHH Production #Peptide Secretion

Discovering Scalable Solutions for VHH and Peptide Production

In the fast-evolving biopharmaceutical landscape, developers are continuously on the hunt for optimal solutions to manufacture proteins and peptides effectively. An upcoming free webinar hosted by Xtalks will delve into this critical topic, featuring discussions on technical advancements in microbial platforms, particularly with C. glutamicum. The live session will be held on September 16, 2025, at 10 AM EDT (4 PM CEST).

Why Focus on C. glutamicum?

Corynebacterium glutamicum has emerged as a leading organism in the production of various biopharmaceuticals. Notably, it presents a scalable and sustainable production platform for heavy-chain-only antibodies (VHHs) and peptides. With its inherent capabilities for high purity and minimal downstream processing complexity, C. glutamicum offers several advantages over traditional production methods.

In the webinar, industry experts from Ajinomoto Co., Inc. will share insights from their research and experiences. Dr. Teruhisa Mannen, Executive Specialist and General Manager of the Biomanufacturing Group at the Research Institute for Bioscience Products & Fine Chemicals, together with Yohei Yamada, Associate General Manager of the Business Development Group, will provide valuable perspectives on these advancements.

Understanding Production Methods

The webinar aims to equip attendees with knowledge about different manufacturing methods, weighing their respective pros and cons when it comes to producing proteins and peptides. Participants will gain insight into:

1. E. coli Expression:
- Widely used and cost-effective; however, it can present challenges in downstream processing and endotoxin issues.

2. Solid-Phase Synthesis:
- Provides rapid flexibility for small-scale peptide manufacturing, though its scalability remains limited.

3. C. glutamicum-Driven Secretion Platform:
- This method stands out for its sustainability and scalability, promising high yield and purity levels, making it suitable for diverse production needs.

These different approaches will be discussed in detail, allowing attendees to understand better how the methods can complement each other and what factors they should consider when selecting the most appropriate production strategy.

The Importance of Choosing the Right Method

Selecting the right method for protein and peptide production is paramount. This choice hinges on various factors, including the unique molecular structure of the intended product, total yield expectations, the current stage of development, and projected volume requirements. The discussions at the webinar will help clarify these aspects, ultimately aiding participants in making informed decisions.

Join the Conversation

To register for the webinar and learn more about the innovative secretion platform for VHHs and peptides, visit the Xtalks website. Engage with industry experts and deepen your understanding of the biomanufacturing landscape.

In conclusion, the upcoming webinar is an invaluable opportunity for drug developers and industry practitioners to explore scalable VHH and peptide production methods, particularly leveraging the capabilities of C. glutamicum. Don’t miss out on the chance to stay current with these pivotal developments in biotechnology.

For further information or to register, visit Xtalks.