#USA #Genomics #Orlando #Callisto #DNA Library

Introducing the Callisto Complete Kit for DNA Preparation

At the Advances in Genome Biology and Technology (AGBT) General Meeting 2026, held in Orlando, Florida, Volta Labs, a frontrunner in next-generation sequencing (NGS) automation, revealed their innovative product, the Callisto Complete Kit. This new kit combines cutting-edge sample preparation chemistry from Watchmaker Genomics with Volta's advanced digital fluidic automation. Together, they offer a fully automated and PCR-free genomic library preparation workflow.

The Importance of PCR-Free Workflows

As whole genome sequencing (WGS) is being more widely adopted in clinical and translational research settings, PCR-free workflows have gained importance. They help mitigate amplification bias, minimize sequencing artifacts, and enable more uniform coverage throughout the genome, especially in G/C-rich areas. However, achieving reproducibility and precision in PCR-free library preparation poses challenges. Automation is crucial for labs looking to produce reliable results without overburdening their personnel.

The Callisto Complete Kit simplifies the process by reducing manual liquid handling, thereby enhancing operator consistency and minimizing variability. This allows laboratories to produce high-quality, reproducible libraries while enabling technical staff to concentrate on more complex tasks.

Statements from Leadership

Udayan Umapathi, CEO of Volta Labs, emphasized the importance of simplicity and accessibility in laboratory workflows: "We designed Callisto to streamline sequencing sample preparation. With our Callisto Complete Kit, labs can execute PCR-free whole genome sequencing protocols with ease, ensuring consistent and high-quality results across a modest throughput."

In agreement, Trey Foskett, CEO of Watchmaker Genomics, highlighted the demand for reliable, push-button solutions in clinical and translational environments. He stated, "For labs needing streamlined WGS without PCR—while not operating at high throughput—the Callisto Complete Kit provides a straightforward and efficient method to implement PCR-free WGS confidently."

Live Demonstration at AGBT 2026

To showcase the capabilities of the Callisto Complete Kit, Volta Labs and Watchmaker Genomics will conduct a joint presentation during the AGBT 2026 event. Attendees are invited to learn more about this groundbreaking kit for DNA library preparation through an interactive session, including a demonstration of the automated WGS workflow without PCR.

About Volta Labs

Founded in Boston, Massachusetts, Volta Labs pioneers the sample preparation landscape by merging digital fluidics, modular workflows, and complete automation into a single platform. The Callisto system uniquely provides high-quality and reproducible NGS library preparation for whole genome, targeted, and customized applications.

About Watchmaker Genomics

Watchmaker Genomics is dedicated to enhancing genomic research and clinical applications through innovative tools. With expertise in protein engineering and next-generation sequencing, they deliver precision reagents and platforms that achieve superior accuracy and cost-effectiveness in molecular analysis. Their commitment to advancing cutting-edge technology supports innovations in cancer detection, epigenetics, and liquid biopsy applications.