#Japan #Yokohama #genome editing #UCAY #BEX

Advancement in UCAY Genome Editing Technology

Japan's homegrown genome editing technology, UCAY, stands out for its ability to edit challenging gene regions that existing methods struggle to address. Notably, UCAY has faced a significant hurdle: the absence of a design tool for identifying the RNA sequences necessary for guiding the editing process (known as guide RNA). Until now, the design of these sequences has relied heavily on the skill and experience of seasoned researchers, making it often a painstaking and inefficient endeavor.

In response to this challenge, the Tokyo Metropolitan Industrial Technology Research Institute (TMITRI) has partnered with BEX Co., Ltd. to develop an innovative guide RNA design tool leveraging bioinformatics. This new tool allows researchers to quantitatively predict effective guide RNA candidates, increasing editing efficiency.

The launch of this guide RNA design tool heralds a new era in genome editing, potentially lowering the costs associated with genomic experiments by suggesting guide RNA candidates that take secondary structure into account. This targeted approach ensures that researchers can optimize their editing processes, making adventure into previously challenging gene territories more feasible.

What is UCAY?

UCAY, which stands for Universal CRNA-guided GE AssemblY, is designed to combat the complexities associated with foreign genome editing technologies that feature intricate licensing structures, often rendering them impractical for use within Japan. The simplicity in licensing with UCAY, combined with its ability to target regions such as repeats—previously deemed difficult to edit—presents a promising opportunity for agricultural and industrial applications. This widespread potential in breeding and other fields is what makes UCAY a vital player in the future of genetic engineering in Japan.

Introducing the Guide RNA Design Tool

The guide RNA design tool not only facilitates efficiency in genome editing but also helps researchers save time and resources by providing insights into editing strategies. By considering the secondary structures of RNA, the tool can propose candidates that hold a higher likelihood of successful editing outcomes. The ramifications for the broader research community are profound, providing a technological advancement that can be utilized across various scientific disciplines.

Presentation at the 48th Annual Molecular Biology Society of Japan Conference

In line with the unveiling of this revolutionary technology, TMITRI and BEX will present their findings during a poster session at the 48th Annual Molecular Biology Society of Japan Conference. The event will take place from December 3 to 5, 2025, at Pacifico Yokohama. They will have their poster on display, with the identifier 1P-031 on December 3 only, and a prominent booth located near the main entrance of the exhibition area to introduce attendees to UCAY.

Join us at this leading forum to learn more about how UCAY and its new guide RNA design tool could transform the landscape of genome editing and its applications in various fields. This collaboration represents a significant step forward in making gene editing more accessible and efficient for researchers.