Bracco and Avicenna.AI Launch UPTUNITY™ | Aneurysm for Brain Health Monitoring

Bracco and Avicenna.AI Introduce UPTUNITY™ | Aneurysm

Milan, November 13, 2026 - In a significant leap forward for brain health technology, Bracco and Avicenna.AI have received FDA 510(k) clearance for their new AI-enabled software, UPTUNITY™ | Aneurysm. This innovative solution is aimed at assisting medical professionals in detecting and assessing brain aneurysms using cerebral arteries computed tomography angiography (CTA) images.

UPTUNITY™ marks the first release in a broader portfolio of clinical decision support tools resulting from the collaboration between Bracco and Avicenna.AI. As brain aneurysms can often be asymptomatic and difficult to identify, this software is designed to integrate seamlessly into the radiologists' reading process. It enhances the ability to spot aneurysms, which occur in approximately one in fifty U.S. adults, underscoring the pressing need for enhanced detection methods.

Cosimo DePinto, Executive Vice President of Marketing and Commercial Operations at Bracco Americas, emphasizes the importance of UPTUNITY, stating, “A small incidental aneurysm on a head CTA can easily be overlooked when the worklist keeps growing.” This solution operates within the familiar reading environment of radiologists, ensuring that the clinical decision-making remains firmly in the hands of the professionals.

UPTUNITY | Aneurysm is more than just a detection tool; it also supports ongoing patient monitoring for known aneurysms. The software is constructed as a computer-assisted detection (CADe) and diagnosis (CADx) support system. It identifies potential saccular brain aneurysms larger than three millimeters and provides critical information regarding their location and size, thus aiding radiologists in evaluation and management.

What sets UPTUNITY apart is its follow-up functionality, designed for quantitative assessment. As Dr. Fabio Tedoldi, Head of Global Research and Development at Bracco Imaging, notes, “For a patient with an unruptured aneurysm, the follow-up scan always brings the same question—has it changed?” This feature not only allows for longitudinal tracking across patient scans but also ensures consistent monitoring, which is vital for effective clinical evaluations.

This FDA-cleared software retains physician control, providing information alongside the review of CTA images. It is critical to note that while UPTUNITY assists in detecting anomalies, it is not meant to replace comprehensive patient evaluations or a full physician review.

Cyril Di Grandi, CEO and co-founder of Avicenna.AI, highlights the collaboration with Bracco, pointing out the synergy that enables this advanced detection technology. “Contrast agents were created to make the invisible visible. A brain aneurysm is exactly that kind of hidden finding, often discovered by chance. UPTUNITY | Aneurysm combines our strength to transform head CTAs into narratives that radiologists can follow,” he explains, reinforcing the partnership's value in enhancing patient care as well as early detection.

The commercial rollout of UPTUNITY | Aneurysm is on the horizon, with Avicenna.AI spearheading its promotion and distribution across the United States. This initiative promises to streamline and enrich the radiology workflow and enhance patient outcomes in brain health management.

Bracco’s commitment to innovation is well-established; the company allocates around nine percent of its annual revenue toward research and development. Their existing AI offerings, such as AiMIFY®, enhance imaging interpretations, and UPTUNITY exemplifies their focus on pushing the boundaries of digital health.

This cutting-edge solution will debut at the upcoming Radiological Society of North America (RSNA) Annual Meeting from November 29 to December 3 in Chicago, where attendees can gain deeper insights into the future of AI in radiology. As Bracco continues to build momentum in Digital Health technologies, UPTUNITY | Aneurysm highlights a pivotal shift in how brain aneurysms can be detected and monitored in clinical practice.

For further details about UPTUNITY | Aneurysm and Bracco’s initiatives at RSNA 2026, please visit Bracco’s website.