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MOBILion Systems Showcases Innovations and Future Plans at ASMS 2025 Conference

MOBILion Systems, Inc., renowned for its groundbreaking work in separation science, is set to make a significant impact at the 73rd Annual American Society for Mass Spectrometry (ASMS) conference from June 1-5, 2025, in Baltimore, MD. The company will spotlight the transformative applications of its MOBIE® High-Resolution Ion Mobility product along with a sneak peek at their cutting-edge proteomics platform, BILLIE™.

MOBILion’s participation is marked by a robust schedule featuring over 50 presentations, both oral and poster, that demonstrate how independent researchers are leveraging the power of the MOBIE system across various domains—ranging from pharmaceutical development to advanced lipidomics and PFAS research. These real-world applications are a testament to the growing adoption of MOBILion’s technologies and the expansive benefits they bring to critical workflows in the scientific community.

At the core of their showcase, MOBILion will introduce early performance results from BILLIE™, integrated with the latest advancement known as Parallel Accumulation Mobility Aligned Fragmentation (PAMAF). This innovative operating mode is designed to improve efficiency in mass spectrometry workflows by addressing traditional speed and sensitivity limitations. According to Dr. Melissa Sherman, CEO of MOBILion Systems, “ASMS provides the perfect platform to reveal the remarkable accomplishments achieved by our users with the MOBIE system and to preview what’s in store with BILLIE.”

The PAMAF approach fundamentally enhances mass spectrometry by replacing the slow quadrupole isolation step with high-resolution ion mobility separation. This results in BILLIE™ achieving MS/MS fragmentation at rates exceeding 500 Hz, effectively utilizing nearly all available ions. Consequently, this innovation not only expedites data acquisition but also amplifies signal sensitivity and precision in quantitative analyses, even in the most complex biological samples.

In a detailed explanation, Dr. Daniel DeBord, Chief Technology Officer, emphasized the significant enhancements PAMAF brings to proteomics research. “For over two decades, the scientific community has grappled with the limitations of traditional MS workflows. With PAMAF, we’re enabling data fragmentation with markedly superior signal-to-noise ratios and achieving speeds up to five times faster than conventional systems,” he noted, expressing excitement for what lies ahead in proteomics at ASMS.

What to Expect from MOBILion at ASMS 2025

MOBILion has curated an informative roster of breakfast seminars scheduled from June 2-4, where leading researchers will share insights and case studies on the application of the MOBIE system. Key sessions will include:

• - June 2: Dr. Sarah Choyke on enhancing forensic PFAS analysis, and Dr. Andrew Feilden on analytical challenges of Bicycle peptides.
• - June 3: Prof. Birgit Schilling and Dr. Joanna Bons discussing PAMAF’s role in proteome changes in acute kidney injury, alongside Dr. Ben Orsburn on the improvements in single-cell proteomics.
• - June 4: Dr. John R. Yates will highlight the impact of PAMAF on precise N-glycosylation analysis and its significance in vaccine development.

Attendees can visit Exhibition Booth #434 to meet the MOBILion team and discover how their advancements are revolutionizing LC-MS workflows through high-resolution ion mobility techniques. There will also be a special afterparty on the evening of June 2 at the Hilton in Baltimore, featuring a chance for peers to connect in a relaxed and festive environment.

For those eager for early insights into the BILLIE platform, there’s an opportunity to become a #BILLIEver VIP member, gaining exclusive access to product updates and developments.

In conclusion, MOBILion Systems is not just a participant at ASMS 2025; it is at the forefront of redefining separation science with its unique SLIM (Structures for Lossless Ion Manipulation) technology. This advancement not only enhances the ability to analyze complex samples efficiently but also signifies a leap forward in proteomics, biomarker discovery, and drug development. As they position themselves at the heart of innovation in the biopharmaceutical landscape of Philadelphia, the future looks promising for both MOBILion and the scientific community.

About MOBILion Systems Inc.

MOBILion Systems is dedicated to transforming separation science and pushing the boundaries of what is achievable through its proprietary technologies. Headquartered in Chadds Ford, Pennsylvania, the company continues to support breakthroughs in various fields, enhancing the capabilities of researchers globally. For more information, visit their website or connect on LinkedIn.