#None #Hamilton #Pillar Biosciences #Nexus 21

Pillar Biosciences and Hamilton Unveil Advanced NGS Library Preparation Method

Pillar Biosciences, in collaboration with Hamilton Company, is making waves in the realm of cancer research with the announcement of their newly validated and commercially released automated next-generation sequencing (NGS) library preparation method for the oncoReveal® Nexus 21 Gene Panel. This innovative addition to Hamilton's Microlab® STAR™ and STARlet™ liquid handling systems marks a significant advancement in automated workflows that promise to enhance efficiency and reproducibility in laboratory settings.

In more detail, the oncoReveal® Nexus 21 Gene Panel is a powerful research-use-only (RUO) NGS assay designed to analyze 21 genes vital to understanding both hematologic (blood) cancers and solid organ cancers. This latest release is particularly noteworthy as it serves as the second validated automation workflow emerging from the ongoing strategic partnership between Pillar Biosciences and Hamilton Company.

Key Features of the Nexus 21 Automation Method

The newly developed method is specifically tailored to support laboratories in automating the streamlined single-tube workflow powered by Pillar’s proprietary SLIMamp® technology. Here are some of the standout features of this automation solution:

1. Efficient Sample Processing

The method utilizes Hamilton’s Multi-Probe Head (MPH) coupled with synchronized on-deck processing, significantly reducing the overall time required for library preparation.

2. Flexible Throughput Options

Depending on the Hamilton model used, laboratories can process between 8 to 96 libraries per run on the STAR system, and 8 to 24 libraries on the STARlet system, with options to select multiple runs of 8.

3. User-Friendly Interface

A guided software interface simplifies various aspects of the process, including deck setup, reagent loading, and run configuration, making the system accessible even to those new to automated workflows.

4. Streamlined Workflow

The automation method considerably lessens manual handling of samples and reagents, while eliminating the need for mandatory mid-run tip reloads, ultimately enhancing the laboratory experience.

5. Economical Reagent Usage

Optimized liquid handling is in place to reduce dead volume, which helps laboratories maximize reagent utilization, saving costs in the long run.

Impact on Cancer Research

As stated by ShiPing Zou, Senior Director of Global Product Management for Pillar Biosciences, the Nexus 21 Gene Panel consolidates a high-value set of targets crucial for both hematologic and solid tumor research. The transition to automation via Hamilton systems not only minimizes manual effort but also supports larger throughput, facilitating quicker and more reliable NGS library preparation utilizing Pillar's proprietary SLIMamp® chemistry.

Michael Mouradian, Vice President of Scientific Strategy and Market Development at Hamilton, adds that this development increases the repertoire of Pillar workflows available for Hamilton automation. It offers researchers increased flexibility as they scale their targeted NGS studies across various types of cancers.

This latest expansion of the Nexus 21 workflow extends the array of validated automation methods offered by Pillar Biosciences for implementation on Hamilton's liquid handling platforms. It provides laboratories with enhanced adaptability in deploying automated NGS workflows across diverse oncology applications.

Both companies remain committed to delivering integrated automation solutions, designed to simplify laboratory adoption and empower researchers to scale their genomic studies confidently.

About Pillar Biosciences

Pillar Biosciences is a leading global provider of next-generation sequencing (NGS) kitted solutions, aiming to enhance operational efficiency and analytical performance in cancer diagnostics. Utilizing proprietary SLIMamp® and PiVAT® technologies, Pillar enables localized testing, thus broadening access to complex molecular diagnostics globally. With an expanding portfolio of IVD and RUO NGS kits focusing on tumor profiling, biomarker analysis, and molecular research, Pillar consistently delivers reliable results, improving laboratory efficiency in both clinical and research environments.

About Hamilton

With over 75 years in the industry, Hamilton Company leads in the design and manufacturing of precision measurement devices, automated liquid handling platforms, and effective sample management solutions. Headquartered in Reno, Nevada, with significant manufacturing and R&D capabilities in Europe, Hamilton caters to the scientific community worldwide, ensuring high-quality solutions and dedication to innovation.

For additional details, visit pillarbiosci.com and hamiltoncompany.com.