Volta Labs Unveils Advanced Library Prep App for Oxford Nanopore Sequencing

Volta Labs Launches New Library Prep App for Nanopore Sequencing

Volta Labs, a leader in genomic applications, is excited to announce the introduction of its Library Prep App designed for Oxford Nanopore's LSK114 on the Callisto™ Sample Prep System. This innovative app is a significant addition to Volta's range of tools, expanding their ability to improve long-read sequencing processes.

The launch, which took place on June 12, 2025, highlights Volta's commitment to facilitating more efficient workflows in genomic laboratories. The Library Prep App is set to enhance flexibility in batching and optimize throughput for nanopore-based DNA sequencing. By automating this critical step, the app allows technicians to redirect their focus toward other essential laboratory tasks, subsequently increasing overall productivity and efficiency.

The development of this app is particularly meaningful for both academic institutions and clinical laboratories, enabling them to reliably prepare libraries for Oxford Nanopore sequencing. As Udayan Umpathi, the Founder and CEO of Volta Labs, states, this application has the potential to transform the experience of those working with sequencing technologies by streamlining previous conventional methodologies.

One of the key advantages of the Library Prep App for Oxford Nanopore LSK114 is its full automation of the library preparation workflow. This automation is designed to preserve DNA integrity while providing cost efficiencies through optimized miniaturized reactions. With Callisto's advanced digital fluidics architecture, early users have reported notable improvements in both operational efficiency and the quality of the libraries produced using the automated LSK114 workflow.

Umpathi emphasizes that the introduction of this app builds upon their earlier success with PacBio HiFi automation. The automation capabilities of the Library Prep App extend beyond mere functionality, as they promise to facilitate population-scale projects without compromising on library quality.

Abdul Mohammed, Volta's Head of Product, echoes these sentiments, pointing out that the genomic community has been eagerly anticipating a solution that simplifies the complexity of traditional automation. The LSK114 app specifically allows laboratories to scale their Oxford Nanopore sequencing efforts while matching the throughput of both the Callisto and PromethION 24 device, which can handle 24 samples simultaneously.

Existing customers of the Callisto platform can take advantage of the Library Prep App as a software update. New installations of the Callisto system will include this app as part of their standard offering. Moreover, the app is supported by specialized reagent kits optimized for the Callisto platform, ensuring consistent performance and ease of ordering while meeting rigorous scientific standards. It is important to note that the Callisto Sample Prep System is designated for research use only.

Overall, Volta Labs has successfully positioned itself at the forefront of genomic advancements, particularly with this landmark development. As the company strives to maximize performance and scalability within the field of genomics sample preparation, their innovative solutions continue to pave the way for future successes in DNA sequencing and beyond. With mounting interest and support from the genomics community, Volta is on a promising trajectory for ongoing innovations and enhanced accessibility in genomic technologies.