Volta Labs Enhances Long-Read Sequencing with New Oxford Nanopore Library Prep Application

Volta Labs Enhances Genomic Capabilities

Volta Labs, known for its innovative genomic applications, announced a significant enhancement to its sequencing capabilities. Their latest offering is the automated Library Prep application for the Oxford Nanopore LSK114, integrated into the Callisto™ sample preparation system. This addition promises to bolster Volta's position in the realm of long-read sequencing, vital for advancing genomic research and clinical applications.

Introduction to the Library Prep Application

The new Library Prep application streamlines the process of preparing DNA samples for sequencing. With this tool, laboratories can optimize batch processing, which significantly increases throughput for DNA sequencing performed using nanopore technology. By automating the workflow, technicians can redirect their time and resources toward other critical laboratory projects, ensuring a more efficient operation overall.

According to the details released by the company, the Library Prep application not only boosts efficiency but also ensures that DNA integrity remains intact during preparation, a crucial factor for the accuracy of genomic analyses. Plus, the cost-effectiveness achieved through miniaturized reactions due to Callisto's unique digital fluidic architecture is a notable advantage for users.

Performance Improvements Observed

Early partners who had access to the application noted remarkable improvements in both efficiency and library quality when utilizing the automated LSK114 workflow. This positive feedback reflects Volta Labs’ commitment to enhancing the capabilities of its products, drawing on feedback from the genomic research community.

Udayan Umpathi, founder and CEO of Volta Labs, expressed excitement about the application, highlighting its potential impact on the Oxford Nanopore community. He stated, "This new application builds on our successes seen with the automation of PacBio HiFi, expanding our efforts to streamline single-molecule sequencing applications. The integration of Oxford Nanopore with Callisto technology is truly game-changing."

Meeting Market Demands

Abdul Mohammed, product manager at Volta Labs, reinforced the application’s relevance in current genomic workflows. He noted, "The genomics community has been eagerly awaiting more accessible automation for long-read library preparation protocols. Our LSK114 application delivers precisely that, allowing labs to escalate their Oxford Nanopore sequencing efforts without the complicated development typically associated with traditional automation—and without compromising on the quality of the sequencing library."

The flexibility of this application enables laboratories to manage up to 24 samples at a time on Callisto and the PromethION 24 system, a valuable enhancement for high-throughput environments like academic research or clinical settings.

Availability and Future Prospects

The Library Prep application for Oxford Nanopore LSK114 is currently available as a software update for existing Callisto customers, as well as being included with all new Callisto installations. This tool is supported by dedicated reagent kits optimized for the Callisto platform, ensuring consistent performance while simplifying the reordering process for laboratories.

As the Callisto system is geared towards research, this application opens up new possibilities for genomic investigations, whether in university-affiliated labs or independent research facilities. Volta Labs is poised to lead advancements in genomic sample preparation as they continue to innovate and respond to market needs.

Conclusion

In a world increasingly reliant on genomic research, Volta Labs’ latest application addresses key needs for efficiency and quality in sequencing. By merging automation with advanced genomic technology, the Library Prep application for Oxford Nanopore is a landmark step forward, aiding researchers in their quest for knowledge at the molecular level. As the sector evolves, solutions such as this will undoubtedly play a pivotal role in the future of genomic applications, providing researchers with the tools they need to overcome current challenges and push the boundaries of science.