#USA #MOBILion Systems #Proteomics #PAMAF #Chadds Ford, Pennsylvania

Transformative Innovations in Proteomics by MOBILion Systems at HUPO 2025

MOBILion Systems, Inc., a leader in separation science, is set to showcase its groundbreaking advancements in proteomics during the upcoming HUPO World Congress, taking place from November 9 to 13, 2025, in Toronto, Canada. The company's Chief Technology Officer, Daniel DeBord, will present the remarkable results of their unique technology known as PAMAF™ (Parallel Accumulation - Mode Alignment Fragmentation), which significantly enhances sensitivity and performance in mass spectrometry for proteomics and multi-omics.

As the field of proteomics increasingly focuses on post-translational modifications (PTMs) and proteoforms, essential indicators in drug development and clinical diagnostics, technologies that improve detection depth and precision are transforming the approach scientists take to biological complexity. MOBILion's PAMAF technology nearly achieves 100% ion utilization, leading the industry with spectral generation rates exceeding 500 Hz. This remarkable performance is made possible through MOBILion's high-speed HRIM (High-Resolution Ion Mobility) separation, reducing reliance on slow quadrupole filtering which often results in information loss.

Dr. Melissa Sherman, CEO of MOBILion Systems, emphasized the revolutionary potential of PAMAF, stating, "In a field where incremental improvements are often seen as significant, PAMAF delivers ion intensity increases from 300% to a staggering 2000%, resulting in vastly enhanced identification rates. These advancements empower researchers to identify thousands of proteins and additional post-translational modifications from smaller sample sizes, paving the way for new frontiers in proteomics, biomarker discovery, and therapy development."

DeBord's presentation will feature experimental data combining MOBILion's MOBIE® HRIM module with existing QTOF platforms. The outcomes show up to a 100-fold increase in fragment ion intensity, identifying three to twelve times more protein groups, paired with a 43% to 53% increase in peptide counts per protein—improvements that grow even more pronounced with minimal sample amounts. The PAMAF operating mode is set to revolutionize single-cell proteomics and quantitative PTM measurements.

DeBord noted, "These findings highlight the enhancement in ion utilization as a crucial factor for performance in mass spectrometry. By eliminating quadrupole filtering and aligning fragmentation with ion mobility, PAMAF enables a more comprehensive and unbiased analysis of complex biological samples, getting us closer to complete coverage of the proteome and proteoforms."

About MOBILion Systems, Inc.

MOBILion Systems is at the forefront of developing high-performance analytical instruments that unveil previously hidden molecular details by integrating SLIM (Structures for Lossless Ion Manipulation) technology with high-resolution mass spectrometry. Its patented HRIM technology enhances separation capacity, sensitivity, and performance across proteomics, metabolomics, lipidomics, and clinical research applications. MOBILion's mission is to empower scientists to accelerate discovery, advance precision medicine, and improve human health by revealing the invisible.

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