#United States #Los Angeles #Empire Genomics #HCR Pro #NISH Technology

Introduction

In a groundbreaking collaboration, Empire Genomics and Molecular Instruments (MI) have unveiled NISH (Neo in situ hybridization), a fully automated and ready-to-use ISH library designed specifically for advanced research applications. This innovative library is exclusively available on the NeoPATH Pro automated staining platform, showcasing the largest selection of ISH probes in the industry.

The Features of NISH

NISH is powered by the HCR™ Pro RNA-ISH assay, significantly streamlining the RNA in situ hybridization process in Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Noteworthy is the astonishing processing time, with runs taking as little as 5.5 hours, which drastically reduces both manual involvement and turnaround times. Researchers will benefit from easy access to more than 17 pre-designed ISH probes, marking a significant enhancement in experimental efficiency.

One of the standout features of the NISH system is its protease-free approach to RNA detection. By omitting protease digestion, the technology preserves the integrity of tissue morphology and protein targets, enabling researchers to conduct their investigations without compromising the quality of the samples. This enhancement is vital for accurate data collection in various research domains.

Expert Insights

According to Dr. Aneesh Acharya, Chief Operating Officer of Molecular Instruments, the clarity of RNA-ISH signals is crucial for research effectiveness. He emphasizes that detecting the right targets while preserving tissue context is the central goal of the technology. With the integration of HCR™ Pro and HCR™ HiFi Probes in the NeoPATH Pro system, molecular biologists are equipped with tools that foster both focused and multiplex RNA-ISH workflows.

This collaboration aims to address the pressing demands in laboratories for greater throughput, consistency, and the practical adoption of automated RNA-ISH technology. High-quality research necessitates reliable and efficient methods, which NISH aims to deliver.

NISH's Role in the Market

As interest in RNA-ISH technologies surges within biomarker research and translational studies, NISH offers a practical solution that simplifies previously complex workflows. Empire Genomics carefully crafted the partnership to provide labs with essential resources to heighten their research capabilities, especially in a landscape where accuracy and speed are paramount.

John Steel, Empire Genomics’ Senior Vice President, highlights that their partnership results in one of the widest arrays of automated ISH and FISH probes combined with a fully automated workflow, allowing labs to conduct experiments with optimized turnaround times. This advancement is particularly significant for research entities working with valuable FFPE material.

Conclusion

The launch of the NISH technology marks a significant milestone in RNA detection methodologies. As part of MI's arsenal of HCR™ imaging solutions, NISH stands poised to transform research approaches related to drug discovery, synthetic biology, and molecular studies. Available now through Empire Genomics, this state-of-the-art ISH library paves the way for evolving standards in tissue-based therapies and research.

For more information on NISH and to view the complete probe menu, visit Empire Genomics. Note that the product is intended for research use only and not for diagnostic procedures.

About the Companies

Molecular Instruments specializes in creating molecular kits powered by their innovative HCR™ imaging platform for various research applications, while Empire Genomics, part of Biocare Medical, provides extensive FISH probes crucial for accelerating the research and clinical testing landscape. Together, they represent a powerful alliance in advancing genomic research.