Piramal Pharma Solutions Enhances Peptide API Facility with Advanced Spray Drying Technology

Piramal Pharma Solutions (PPS), a prominent global Contract Development and Manufacturing Organization (CDMO), has taken a significant step in pharmaceutical innovation by expanding its specialized peptide facility located in Turbhe, India. The newly installed spray drying system, equipped with Band-5 containment capability, boasts independent ventilation, nitrogen supply, and advanced control systems tailored for the formulation of complex molecules, including peptides and highly potent active pharmaceutical ingredients (HPAPIs).

This strategic enhancement allows PPS to address the intricate challenges associated with peptide formulation and to satisfy the increasing demand for these innovative therapeutic agents. The advanced spray drying technology converts liquid formulations into dry powders efficiently, enabling drug developers to enhance bioavailability while achieving precise particle sizes critical for stability, particularly in temperature-sensitive peptides.

Dr. Jordi Bacardit, the Global Technical Lead on Peptides at PPS, emphasizes the importance of this upgrade. The spray drying process addresses critical challenges presented by the inherent instability and sensitivity of peptide compounds to manufacturing conditions. By allowing stringent control over temperature and solvent environments, it is now possible for PPS to assist its partners in producing stable and high-quality peptide formulations for patients in need around the world.

With capabilities designed to handle low-volume, high-potency batches, the facility is able to support a feed rate of up to one liter per hour, with potential for drying concentrated solutions containing up to 30% water. This presents substantial benefits for the formulation of biomolecules and larger peptides, while also allowing for the processing of smaller molecules in select scenarios.

The new spray drying unit operates as a closed system, ensuring safe handling of high-potency compounds and organic solvents that warrant a Band 5 safety level. To reinforce the safety measures, the processing area complies with ISO Class 8 cleanliness standards, maintaining rigorous control over environmental conditions throughout operations. This advanced setup, featuring airlocks at in- and out- points, personnel isolation, and dedicated cleaning areas, is designed to facilitate secure processing and management of the delicate materials involved.

This upgrade positions Piramal Pharma Solutions as a trusted partner in various therapy areas, highlighting its commitment to meet the growing significance of peptides and other complex molecules in modern medicine. Moreover, this advancement solidifies PPS's reputation as a reliable provider of end-to-end development and manufacturing solutions throughout the drug lifecycle.

Piramal Pharma Solutions is dedicated to offering a comprehensive range of services, including research solutions, process and pharmaceutical development, clinical trial supplies, and commercial delivery of APIs, alongside finished dosage forms. Their proficiency extends to developing and manufacturing high-potency APIs, antibody-drug conjugates, sterile filling, and final formulation of products, as well as specialized services in biologics development, encompassing vaccines and gene therapies.

For more information on Piramal Pharma Solutions and their latest advancements in pharmaceutical manufacturing, please visit their official channels on LinkedIn and Facebook.