The SEPSIS Act (S.1929) was notably reintroduced in the U.S. Senate on June 5, 2025, by END SEPSIS, highlighting a significant move towards tackling the serious issue of sepsis in the healthcare system. First presented in September 2024, this bipartisan legislation has gained momentum, exemplified by the support from Senate Majority Leader Chuck Schumer (D-NY), Senator Susan Collins (R-ME), and Senator Andy Kim (D-NJ). This broad backing illustrates an increasing recognition of the need for effective legislative measures to address sepsis, a condition causing hundreds of thousands of deaths annually.
Sepsis presents an enormous challenge to U.S. healthcare, with over 350,000 fatalities each year and financial repercussions exceeding $60 billion. This deadly condition emerges when an infection leads to injury throughout the body, making awareness and prompt treatment crucial. The newly reintroduced SEPSIS Act underlines the necessity for immediate action by allocating a proposed $20 million annually to benefit key programs led by the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), and Centers for Medicare & Medicaid Services (CMS).
Key objectives of the SEPSIS Act include:
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Enhanced Outreach and Education: The legislation pushes for increased education in hospitals to encourage the adoption of the CDC’s comprehensive sepsis guidelines, with the aim of establishing core elements in hospital sepsis programs.
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Finalizing Sepsis Outcome Measures: The bill strives to create a standard outcome measure for sepsis, which can dramatically influence healthcare systems. This would ensure a consistent approach to sepsis management across hospitals, incentivizing improvements that could result in reduced mortality and overall healthcare costs.
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Data Transparency and Quality Improvement: The SEPSIS Act mandates hospitals to publicly report their sepsis outcomes, driving competition among facilities to enhance their care process and invest more in sepsis treatment programs.
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Invest in Pediatric Sepsis: Additionally, the bill aims to improve data collection specifically related to pediatric sepsis cases, recognizing the unique challenges faced in treating younger populations.
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Incentive Programs: Establishing incentives for hospitals to advance their sepsis outcomes is another critical aspect, fostering an environment where improvement is both a priority and a rewardable achievement.
In its efforts to move this vital legislation forward, END SEPSIS returned to Capitol Hill to engage with key members of the Senate Health, Education, Labor and Pensions (HELP) Committee. During these discussions, the organization highlighted the overwhelming burden of sepsis on American families and the healthcare system. Co-founders Ciaran and Orlaith Staunton underline that this act represents a crucial juncture in the ongoing battle against avoidable sepsis deaths. They expressed hope that, with bipartisan backing and robust support from healthcare leaders, the SEPSIS Act can lead to a coordinated federal response that effectively saves lives.
END SEPSIS has dedicated itself to a comprehensive approach involving collaboration between Congress, federal agencies, and research institutions. The reintroduction of the SEPSIS Act is not merely a legislative formality; it symbolizes a commitment to finding practical solutions to end the sepsis crisis. Through continued advocacy, the organization aims to achieve significant policy changes that will have lasting impacts in the realm of public health.
While the SEPSIS Act is a step in the right direction, it remains critical for advocates, healthcare professionals, and the public to work together. Increasing awareness of sepsis, supporting legislation like the SEPSIS Act, and ensuring better treatment protocols are essential in changing the course of this preventable condition, ultimately saving countless lives in the process. END SEPSIS will keep fighting for these changes to ensure no more families suffer the devastating consequences of sepsis.
For more information about the SEPSIS Act and ongoing advocacy efforts, visit
END SEPSIS.