#USA #Boston #Volta Labs #Callisto #Twist Bioscience

Introduction

Volta Labs has made a significant advancement in the realm of genomic applications by launching the Twist Fast Hyb application. This new addition complements the existing Twist Standard Hyb v2, providing laboratories with a completely automated solution for target enrichment, ensuring reproducibility and same-day results.

About Twist Fast Hyb

On June 12, 2026, Volta Labs announced this groundbreaking release, which promises to transform the workflow of genomic sequencing. The Twist Fast Hyb application works in tandem with the Callisto™ Sample Prep System, designed to streamline sample preparation for next-generation sequencing (NGS). As a collaborative effort with Twist Bioscience, this innovative solution automates one of the most intricate and labor-intensive steps in sample prep—target enrichment through hybridization.

Benefits of Automation

Historically, target enrichment has presented numerous challenges in automation due to the need for precise temperature control, repeated manipulations of magnetic beads, and meticulous manual techniques. These factors often introduce variations between different tests and operators. With the Twist Fast Hyb application, laboratories are freed from these burdens. Once amplification is completed, Callisto autonomously executes the protocol, managing temperature control and bead handling without any need for operator intervention, allowing for consistent results.

Consistency and Performance

One of the standout features of the Twist Fast Hyb application is its ability to maintain consistency across different runs and eliminate variations caused by disparate operators—a common source of errors in manual target enrichment. Testing has demonstrated that performance metrics of sequencing achieved with Callisto match those obtained via manual preparation. Key quality indicators such as Fold-80, coverage uniformity, and dropout rates—specifically in AT/GC-rich regions—highlight the impressive reliability of the automated system.

Response to Industry Needs

Udayan Umapathi, CEO and founder of Volta Labs, emphasized the importance of automation in the often challenging process of target enrichment. He noted that small technical variations can vastly alter outcomes, positioning Twist Fast Hyb as a fully automated version of the hybridization protocol that delivers equivalent performance to traditional manual methods but with considerably faster turnaround times—allowing laboratories to produce sequencing results within hours rather than overnight.

Versatile Applications

This application is particularly valuable for labs conducting comprehensive cancer profiling, whole exome sequencing, and other targeted sequencing applications. Researchers are under constant pressure to deliver results rapidly while managing operational complexity and limited human resources. By extending the range of hybrid capture options available on Callisto, this solution not only meets urgent performance demands but also provides the flexibility labs need.

Conclusion

With the launch of Twist Fast Hyb, Volta Labs has expanded its automation offerings significantly, allowing laboratories to execute all their hybrid capture procedures on a single platform. Emily M. Leproust, CEO and co-founder of Twist Bioscience, noted that this advanced automation minimizes barriers to adoption, making it easier for clients to implement high-performing target enrichment solutions without operational burdens associated with manual workflows.

In a field where efficiency and consistency are critical, the Twist Fast Hyb application represents a pivotal advancement for genomic laboratories, ensuring that precision and speed go hand in hand. With it now being integrated into Callisto, labs are better equipped than ever to tackle the demands of modern genomic sequencing openly and efficiently.

About Volta Labs

Founded in 2018 at MIT, Volta Labs is at the forefront of advancing genomic sample preparation with the Callisto™ Sample Prep System. Leveraging exclusive electrowetting technology, Callisto delivers fully automated DNA and RNA extraction and library preparation solutions for major sequencing platforms, including Illumina and PacBio. This innovation cuts down on intervention time by up to 80%, offering unrivaled reliability for various sample types and chemical compositions. For further insights, visit Volta Labs.