#India #Piramal Pharma #API Production #Turbhe

Piramal Pharma Solutions Unveils Advanced Spray Drying Unit

Piramal Pharma Solutions (PPS), a prominent global Contract Development and Manufacturing Organization (CDMO), has taken a significant step forward with the installation of a cutting-edge spray drying unit at its peptide production facility located in Turbhe, India. This strategic expansion addresses complex formulation challenges and meets the growing demand for innovative peptide drugs.

The newly operational spray drying unit, designed with a class 5 containment level, is specifically tailored to facilitate the development of complex molecules, including peptides and highly potent active pharmaceutical ingredients (HPAPIs). This state-of-the-art technology converts liquid formulas into dry powders in a single step, enhancing drug biodistribution and allowing for safe processing of sensitive compounds. Given that peptides often lack stability at high temperatures, spray drying offers an efficient and gentle approach that safeguards the molecular integrity of these active ingredients.

Equipped with its own air processing units and a nitrogen feeding system, the new suite enhances the facility's capacity to tackle the intricacies associated with peptide and biomolecule formulations. The closed-loop design of the spray drying unit ensures rigorous environmental controls, featuring specialized HVAC systems, airlocks, isolation spaces for operators, and dedicated cleaning zones. These measures enable the safe handling of potent compounds and organic solvents, adhering to stringent class 5 containment standards.

Designed for small volume, high-concentration batches, this innovative unit has the ability to process feeds of up to one liter per hour, making it particularly advantageous for formulating biomolecules and larger peptides. Furthermore, it accommodates solutions with water content as high as 30%, highlighting its versatility. Under optimal conditions, the technology can also be adapted for smaller molecule formulations, making it a valuable asset in the pharmaceutical development landscape.

Dr. Jordi Bacardit, Global Technical Lead on Peptides at PPS, remarked, "Peptides highlight some of the most complex formulation challenges in pharmaceutical development due to their inherent instability and sensitivity to processing conditions. The introduction of the spray drying unit in Turbhe allows us to provide our partners with stable and high-quality peptide formulations that patients can rely on."

As peptides and complex molecules play an increasingly essential role in modern pharmaceuticals, the expansion of PPS's spray drying capabilities reaffirms its standing as a trusted partner across a broad spectrum of therapeutic areas. This investment not only demonstrates PPS's commitment to quality and innovation but also aims to accelerate the delivery of critical medical solutions to patients worldwide.

About Piramal Pharma Solutions

Piramal Pharma Solutions is an end-to-end development and manufacturing organization that caters to various stages of the drug lifecycle. The company operates a globally integrated network across several facilities in North America, Europe, and Asia, providing a comprehensive array of services from drug discovery to clinical supply and commercial manufacturing. The organization prides itself on its ability to deliver specialized services, including the development of highly potent active pharmaceutical ingredients, sterile fill/finish capabilities, and peptide-related services. By continuously evolving its capabilities, PPS adapts to the rapidly changing landscape of pharmaceutical development, facilitating the creation of therapeutic solutions that meet global health needs.

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