#India #spray drying #Piramal Pharma Solutions #Peptide API #Turbhe

Piramal Pharma Solutions Enhances Peptide Production

Introduction
Piramal Pharma Solutions (PPS), a prominent global player in the Contract Development and Manufacturing Organization (CDMO) sector, has recently inaugurated an advanced spray drying suite at its peptide development facility in Turbhe, India. This strategic move is designed to tackle the intricate formulation challenges posed by peptide APIs and other complex molecules, which are increasingly vital in modern pharmaceuticals.

State-of-the-Art Facility
The newly installed spray drying suite boasts a Band 5 containment capacity and features specialized systems for air handling, nitrogen supply, and precise control mechanisms. This infrastructure not only enhances the facility's capabilities but also reinforces PPS's commitment to meeting the rising demand for cutting-edge pharmaceutical solutions.

Advantages of Spray Drying
Spray drying is a transformative technology that converts liquid formulations into dry powders in a single process. This method significantly enhances drug bioavailability and allows for precise control of particle sizes while maintaining the stability of sensitive compounds. For peptides, which are often unstable at elevated temperatures, this technique is especially beneficial as it minimizes the risk of degradation and supports the development of stable, high-quality dosage forms.

Operational Excellence
The new spray drying suite operates as a closed-loop system, equipped with advanced safety protocols including specialized HVAC systems and airlocked entry/exit points. This operational design is crucial for safely handling potent compounds and organic solvents, which require stringent containment measures. Additionally, the processing area maintains ISO Class 8 cleanliness standards, ensuring a controlled environment for all operations.

Efficiency and Flexibility
Engineered to process small-volume, high-potency batches, this new suite supports a feed rate of up to 1 liter per hour. It can efficiently spray dry highly concentrated solutions, making it particularly adept for formulating biomolecules and larger peptide constructs. The suite's capabilities also extend to low-volume small-molecule formulations, showcasing its versatility within PPS’s service offerings.

Expert Insights
Dr. Jordi Bacardit, Global Technical Lead on Peptides at PPS, emphasized the importance of this technological enhancement, stating, "Peptides present some of the most intricate formulation challenges in pharmaceutical development due to their inherent instability. The introduction of the spray drying suite empowers us to maintain tight control over critical parameters like temperature and solvent environment, thereby enhancing the stability of our peptide formulations."

Conclusion
With the demand for complex molecules like peptides on the rise, Piramal Pharma Solutions' investment in advanced spray drying technology positions them as a trusted partner in the pharmaceutical industry. Their commitment to high-quality production processes aligns with the industry's needs for innovative therapeutic solutions, ultimately benefitting patients globally.

About Piramal Pharma Solutions
Piramal Pharma Solutions (PPS) offers a comprehensive suite of development and manufacturing solutions across the drug life cycle, serving clients through an integrated global network. Their extensive expertise in pharmaceuticals includes a diverse range of services from drug discovery to commercial supply, ensuring that customers receive superior support throughout every stage of their projects. With innovative solutions such as the new spray drying suite, PPS continues to solidify its position at the forefront of pharmaceutical manufacturing.