#USA #Boston #Volta Labs #Twist Bioscience #Hybridization Capture

Volta Labs Launches Cutting-Edge Automated Hybridization Capture Workflow

In a significant advancement for genomic research, Volta Labs, a pioneer in next-generation sequencing (NGS) sample preparation solutions, has unveiled its new automated Hybridization Capture application for the Twist Standard Hybridization v2 kit, integrated into the Callisto platform. This innovative workflow combines industry-leading hybrid capture chemistry from Twist Bioscience with Volta's fully automated Callisto technology, streamlining the process and ensuring high consistency in enrichment outcomes for researchers.

The Collaboration between Volta Labs and Twist Bioscience

Volta Labs has long been at the forefront of developing sophisticated methods to enhance genomic analyses. Their partnership with Twist Bioscience brings together robust technology and expertise, yielding a powerful tool for laboratories engaged in DNA sequencing. “By combining our validated v2 kit with the unique architecture of Callisto—known for its precise temperature control—we've optimized the hybrid capture workflow,” said Udayan Umapathi, CEO of Volta Labs. He emphasized that the new system not only simplifies the protocols but also makes them more reliable and user-friendly, suitable for any lab setting.

Benefits of Callisto for Hybridization Capture

The introduction of Callisto into the hybridization capture process marks a significant upgrade in workflow efficiency. Traditionally, hybridization capture has been seen as a labor-intensive task requiring specialized technicians. However, the Callisto platform breaks down these barriers by automating critical steps. Its unique design allows for meticulous handling of magnetic microspheres and maintains consistent temperature control throughout the hybridization process. This innovation is crucial in providing uniform performance that eliminates the variability often seen in manual or semi-automated methods.

How Callisto Transforms Workflow

One of the standout features of Callisto is its ability to automate the complex steps involved in hybrid capture. For researchers, this means a reliable and straightforward workflow that produces consistent target enrichment results. As Umapathi noted, this reduces the frequency of required repeats, which in turn lowers sequencing costs and ensures comprehensive coverage across various sequencing panels.

The Twist Standard Hybridization v2 Kit

Thoroughly engineered, the Twist Standard Hybridization v2 kit is crafted to deliver superior sensitivity and uniform coverage for targeted regions of interest. With its silicon-based platform capable of large-scale DNA synthesis, Twist provides NGS tools with unmatched precision. “We have developed our Twist NGS tools to empower our customers to accelerate research while minimizing downstream sequencing costs,” explained Emily M. Leproust, CEO and co-founder of Twist Bioscience. The synergy of Twist’s hybridization kit with Volta's Callisto system clearly exemplifies innovation that optimizes research workflows, enabling exceptional productivity and efficiency for users.

Conclusion

In conclusion, the integration of Volta Labs’ automated workflow with the Twist Standard Hybridization v2 kit represents a major leap forward in genomic research capabilities. By simplifying the hybridization capture process, researchers now have access to a powerful and streamlined tool that enhances reliability while maximizing performance. As Volta Labs continues to innovate and improve upon existing methodologies, the future of genetic analysis looks bright.

For more information about this groundbreaking application, please visit Volta Labs’ Hybrid Capture Application page.

About Volta Labs

Volta Labs is a genomic applications company focusing on advanced digital fluidics platforms to maximize performance and scalability in genomic sample preparation, delivering unmatched consistency. Discover more about their products and services at Volta Labs Official Website.