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Expanding Bispecific Purification Strategies

As the demand for bispecifics and complex biologics in the pharmaceutical industry grows, there is a notable shift towards enhancing purification strategies. A crucial upcoming webinar hosted by Xtalks is set to shed light on innovative purification techniques that can streamline the development of these advanced biological therapies.

Understanding the Challenge

The rise of bispecific molecules challenges traditional purification protocols typically employed for monoclonal antibodies (mAbs). These complex biologics often present intriguing impurity profiles that standard mAb platforms struggle to address. Unresolved impurities, including product-related variants, aggregates, and host cell proteins, necessitate robust purification strategies. In this context, downstream teams are under increasing pressure to deliver purification processes that are not only effective but also scalable and efficient.

Key Insights from the Webinar

Scheduled for September 17, 2026, this free webinar will delve into alternative purification approaches. The featured speaker, Maelia Uy-Gomez, Field Application Scientist from Astrea Bioseparations, will guide attendees through various strategies that go beyond conventional platform methods.

One focal point will be selective capture techniques designed to address complex impurity challenges directly, providing wider options than standard methods. The session will also explore polishing strategies with a specific emphasis on mixed-mode chromatography, which offers new avenues for impurity separation that may be crucial for achieving high purity levels during scale-up processes.

Innovations in Purification

Attendees can expect to learn about:

• - Selective Capture Strategies: Techniques aimed at enhancing the initial purification phase specifically for Fc and non-Fc antibodies.
• - Polishing Accelerations: Utilizing mixed-mode chromatography, which blends different separation mechanisms to improve purification efficacy.
• - Case Studies: Real-world examples demonstrating the successful application of these innovative strategies, showcasing methods for addressing complex impurities effectively.

Impact on Process Development

The webinar will emphasize the significance of adopting a strategy that prioritizes outcomes over a one-size-fits-all platform solution. This approach not only aids in overcoming the limitations of standard purification protocols but also supports informed decision-making during the development process. It can lead to refined impurity clearance, enhanced recovery rates, and a greater understanding of the process—all essential factors in the successful commercialization of bispecifics.

Attendees will gain insight into how leveraging differentiated mixed-mode chromatography may reveal purification possibilities otherwise overlooked by conventional screening techniques, particularly vital in cases involving closely related impurities that complicate traditional methods.

Register Now

If you are involved in biopharmaceuticals and are looking to advance your understanding of bispecific purification strategies, don’t miss out on this informative session. Register now for the webinar on September 17, 2026, at 10 AM EDT (4 PM CEST).

By engaging in this webinar, professionals will benefit from expert perspectives, network with peers, and stay updated with cutting-edge developments in the field of biopharmaceutical purification practices.

Join the life science community at Xtalks and be part of the transformation in purification strategies for bispecifics and complex biologics.

For further details and to secure your spot, visit Xtalks.

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