#USA #Pleasanton #ADCs #Unchained Labs #Stunner

Unchained Labs Enhances ADC Characterization with Stunner

Unchained Labs, a pioneering name in life sciences, has made a significant advancement in the characterization of antibody-drug conjugates (ADCs) with the launch of a new application called ADC Decode, integrated into their Stunner platform. This innovative tool arrives at a time when the complexity of ADCs poses unique challenges for researchers, particularly during the early development phases where sample specifics are often unclear.

Understanding ADCs and Their Challenges

Antibody-drug conjugates are intricate therapeutic compounds that combine antibodies with cytotoxic drugs. Their precise characterization is essential for effective development, yet it can be a daunting task due to overlapping signal issues presented by traditional UV/Vis methods. These methods require ideal sample inputs to yield accurate results, which is often not feasible in the initial stages of the development process.

Moreover, conventional analytical tools, while robust, can be excessively complicated for quick screenings, which consume valuable samples and stall throughput with lengthy method development cycles. Recognizing the pressing needs in this area, Unchained Labs set out to simplify the ADC screening process, making it faster and more efficient.

The Solution: Stunner and ADC Decode

With the new ADC Decode application on Stunner, researchers can now quickly characterize up to 96 samples simultaneously, receiving reliable data on drug-antibody ratios (DAR), concentrations, and particle sizes. This capability is groundbreaking, as it effectively separates and identifies the contributions of both the antibody and the drug, resolving overlapping signals that often hinder conventional UV/Vis methods.

What sets Stunner apart is its dual approach, combining UV/Vis spectroscopy with dynamic light scattering techniques. This method not only speeds up the screening process but also enhances accuracy, allowing for timely decision-making early in development.

Krystin Schmidt, the Vice President of Marketing at Unchained Labs, celebrated the launch, remarking, “ADCs are exploding, and researchers need a fast way to screen conjugates before investing in deeper characterization. Stunner’s new ADC Decode application serves up the simplest, most walk-up way to get DAR and concentration analysis.”

Implications for Researchers

The introduction of this application is expected to have far-reaching implications for researchers working in biologics and gene therapy fields. With the ability to streamline the characterization process, researchers can reduce time and resource expenditure, enabling them to focus on advancing their projects with confidence. Fast and reliable characterization means researchers can advance their understanding and knowledge of ADCs while optimizing their developmental workflows.

About Unchained Labs

Unchained Labs is committed to redefining the tools and technologies available to researchers in the biologics and gene therapy sectors. The company is driven by the mission to provide innovative solutions that bridge the gaps in existing methodologies, thereby enhancing the scientific work researchers perform daily. Based in Pleasanton, California, Unchained Labs continues to lead the way in advancing life sciences, ensuring that researchers are equipped with the tools they need to break through barriers in their research pursuits.

For more information about Stunner and the ADC Decode application, you can visit Unchained Labs' official website.