#Japan #Skincare #Osaka #I-ne #Liposome

I-ne's New Liposome Technology for Nighttime Skincare

I-ne Co., Ltd., headquartered in Osaka, Japan, has announced an exciting breakthrough in skincare technology. This innovation involves a new formulation featuring two distinct types of liposomes, providing controlled penetration and sustained release of beneficial ingredients into the epidermis and dermis. The development aims to optimize the effectiveness of skincare products used during the night, when the skin is most receptive to absorption.

The Need for Enhanced Penetration

In order to maximize the efficacy of skincare products, it is vital to deliver beneficial ingredients deep into the skin's cells, particularly the epidermis and dermis. However, the stratum corneum, a barrier protecting the skin, can hinder the penetration of these components. Consequently, not all ingredients reach their intended targets within the skin. Moreover, the cellular processes of absorption, digestion, and excretion can vary significantly among different ingredients—some might have short effective periods. Therefore, applying a large quantity of products at once may not ensure lasting results.

During sleep, the skin is prone to dryness and friction, and frequent reapplication of cosmetics is not feasible. As such, a sustained release of active ingredients is crucial to maintain their effectiveness overnight.

The Revolutionary Liposome Technology

Utilizing the unique properties of two types of liposomes, I-ne has developed an innovative formulation—marking it as the first of its kind in Japan. This new delivery system is designed to provide a staggered release of beneficial ingredients throughout the night.

Evaluation Methods

To assess the capabilities of this new technology, I-ne employed sophisticated evaluation methods.
1. Penetration Effectiveness: Samples infused with specific liposomes and fluorescent dyes were created, followed by tests using three-dimensional cultured skin to verify their penetration abilities.
2. Sustained Release Assessment: Fluorescent dye-laden liposomal samples were evaluated over time to determine the gradual release of the dye.

Evaluation Results

• - Immediate-Action Liposomes: These demonstrated effective penetration up to the epidermis, as shown in fluorescence intensity models.
• - Sustained-Action Liposomes: These were noted for their ability to permeate deeper into the dermis, providing prolonged effects.

The sustained-action liposomes released their beneficial components gradually, enhancing the overall skin benefits throughout the night.

Conclusion

The combination of these two types of liposomes not only allows for swift delivery of beneficial ingredients to the epidermis but also ensures a deeper, slower infusion into the dermis. This technique represents a significant breakthrough in the realm of skincare innovation, aligning perfectly with I-ne's commitment to enhancing the quality and effectiveness of nighttime beauty routines.

Understanding Key Terms

• - Liposomes: These are spherical vesicles composed of lipid bilayers, capable of encapsulating ingredients. They are widely used as carriers for active compounds in cosmetics and pharmaceuticals, enhancing skin penetration and controlled release.
• - Sustained Release: This term refers to a mode of delivery where beneficial ingredients are released slowly over time, extending their impact beyond immediate release. This is particularly crucial in drug delivery, reducing the frequency of administration.
• - Three-dimensional Cultured Skin: This is an artificial skin model created by culturing skin cells, often used as a substitute in testing skincare products for safety and efficacy.

Company Overview

• - Name: I-ne Co., Ltd.
• - Founded: March 2007
• - CEO: Yohei Onishi
• - Location: 541-0058 Osaka, Japan, 4-1-2 Nanko, Chuo-ku, 8th Floor, Midosuji Building
• - Website: I-ne Official

Main Brands

• - BOTANIST
• - SALONIA
• - YOLU
• - DROAS
• - Qurap
• - Tearal
• - SOLAMY
• - ReWEAR