#Sweden #Uppsala #Navinci #Naveni Plex #spatial interactomics

Navinci Launches Naveni® Plex Omni Service

Navinci has recently unveiled its groundbreaking Naveni® Plex Omni Service, aimed at revolutionizing research in spatial interactomics. This service provides researchers with a unique opportunity to engage directly with advanced multiplex in situ proximity ligation assay (misPLA) technology, which is integral to studying protein interactions in their native biological context. The service is operated by the very experts who developed this innovative technology, ensuring high-quality results and streamlined workflows.

Enhancing Research Capabilities

The Naveni® Plex Omni Service enables scientists to map protein functions and their networks in a spatial context. This critical capability allows for better understanding of fundamental biological processes, disease progression, and the prediction of treatment outcomes. By utilizing this technology, researchers can simultaneously observe up to eight protein-protein interactions, individual proteins, or phosphorylation states in Human Formalin-Fixed Paraffin-Embedded (FFPE) samples. Such versatility is essential for dissecting complex biological mechanisms, including tumor-stroma interactions and immune cell functionality.

Furthermore, the technology addresses significant research challenges, such as determining why some cancers evade immune detection and why patients exhibit varied responses to immunotherapies. This service provides an edge by allowing scientists to generate reliable data from complex biological questions that had previously been difficult to tackle.

Proprietary Technology

Navinci’s proprietary misPLA technology utilizes antibody-oligonucleotide pairs that form amplifiable DNA upon proximity binding. This enables the rolling circle amplification method, which allows for accurate detection of protein interactions and modifications, even in cases where targets are rare or transient. By focusing on precise and efficient detection methods, researchers can draw meaningful conclusions from their experiments without being bogged down by technical optimizations.

A Service Designed by Experts

To facilitate optimal usage of this pioneering technology, Navinci is offering its Naveni® Plex Omni Service where the assay will be executed by the very experts who designed it. This unique offering allows researchers to concentrate on deriving insights from their findings rather than getting involved in technical adjustments. With a streamlined process guiding users from panel design through to data delivery, this service marries cutting-edge technology with expert consultation.

Researchers can opt to design custom 4-8-plex panels based on validated targets or choose from pre-validated options covering key research areas like MAPK signaling pathways, immuno-oncology, and TCR/BCR profiling. This tailored approach is aimed at ensuring that the technology addresses the specific needs of various research sectors.

Collaboration and Future Insights

In a significant step showcasing the potential of this service, Navinci conducted a proof-of-concept study in partnership with Uppsala University. The findings of this collaborative effort were published on BioRxiv, further establishing the credibility and scientific merit of the Naveni® Plex Omni Service. Researchers interested in enhancing their investigations in spatial interactomics are encouraged to reach out for more information on designing tailored panels and accessing this state-of-the-art service.

For additional inquiries regarding the Naveni® Plex Omni Service, please contact the CEO, Jenny Sundqvist, via email. Researchers can also visit Navinci's Technology page for more details.

In conclusion, Navinci's launch of the Naveni® Plex Omni Service marks a significant advancement in the field of spatial interactomics. By providing unparalleled access to sophisticated technology and expertise, Navinci is set to empower researchers seeking deeper biological insights.