#Japan #Tokyo #Sake #Regenerome #Longevity Fund

Exploring the Intersection of Sake and Longevity

On August 8, 2025, Regenerome Inc., a subsidiary of Space Seed Holdings, held a symposium titled "The Potential of Sake and Longevity" at the TAKANAWA GATEWAY Link Scholars’ Hub in Tokyo. This event was part of the startup investment program "Fermentation and Longevity Fund," aimed at bridging scientific understanding and commercialization in the fields of fermentation and longevity.

Addressing Modern Challenges

Japan faces a significant gap between average life expectancy and healthy life expectancy, leading to increased healthcare costs and quality of life issues associated with aging. At the symposium, experts discussed how oxidative stress, cellular senescence, and tissue homeostasis relate to these challenges. The research presented highlighted the potential benefits of sake, particularly through its fermentation processes and the use of sake lees.

Sake, with its unique interaction of rice, koji mold, and yeast, contains diverse metabolites (such as amino acids, peptides, organic acids, and glycosides like α-Ethyl-D-Glucoside) that may positively influence human redox homeostasis, intercellular communication, and metabolic responses. Such compounds are anticipated to contribute to outcomes related to reverse aging and skincare through complex biochemical interactions.

Highlights from the Symposium

The symposium featured various discussions on cutting-edge research and technologies.

Development of the Exosome-Sorter

One of the key topics was the development of an "exosome-sorter," which can accurately select human-derived exosomes. This technology promises enhanced throughput and could potentially integrate with existing medical devices, paving the way for applications in diagnostic settings within healthcare environments.

High α-Ethyl-D-Glucoside Sake Development

Another exciting topic was the exploration of high α-EG sake, addressing its benefits and discussing the brewing process optimizations that could increase α-EG content without compromising flavor quality.

SAKESOME: Functional Nanoparticle Research

The exploration of sake-derived nanoparticles—referred to as SAKESOME—was highlighted, investigating compounds like ergothioneine, agmatine, α-EG, and deferriferrichrome for their anti-aging potential. The speakers proposed a hypothesis regarding the impacts of accelerated aging mechanisms in extreme environments, such as outer space.

SAISEI Regenerome Supplement

The SAISEI Regenerome supplement was introduced, which contains a blend of Euglena gracilis, sake lees powder, Kalahari melon powder, and high-purity ergothioneine aimed at cellular-level aging care. The development was informed by longevity research conducted in Okinawa, known for its Blue Zone status, where residents enjoy exceptional longevity.

A Gathering of Innovators

The symposium attracted industry professionals, researchers, and media personnel. The program included a presentation of welcome drinks from Tsunan Brewery, an overview of their "Brew for Future" concept, and insightful lectures from industry leaders.

Notable Speakers

1. Inari Watanabe (SSI Sake Academy Instructor): Discussed "What is Sake?"
2. Kengo Suzuki (CEO of Regenerome): Presented the potential of sake in aging care, as well as the details of the Fermentation and Longevity Fund.
3. Tsunan Brewery: Explained the sake upcycling project, showcasing their commitment to sustainable practices.

The Fermentation and Longevity Fund

The Fermentation and Longevity Fund, which operates under Space Seed Holdings and Regenerome, supports innovative solutions in the fields of fermentation technology and longevity sciences. By investing in early-stage projects and proof-of-concept studies, the fund accelerates the application of research in real-world scenarios while fostering partnerships among academia, industry, and startups.

About Regenerome Inc.

Regenerome aims to provide new solutions for aging suppression and regenerative medicine through the application of nanoparticles like exosomes. With a focus on understanding how these nanoparticles function biologically, Regenerome seeks to develop medical technologies that leverage nanotechnology for enhanced health outcomes, including potential applications in space medicine.

For more information, visit Regenerome.

About Tsunan Brewery

Located in Niigata, Tsunan Brewery produces sake using natural water from the surrounding mountains. They are dedicated to a brewing philosophy that merges innovation and coexistence with nature. Recently winning the Niigata Governor's Award at the Echigo-style Sake Brewing Techniques Championship, they continue to emphasize quality and sustainability in their practices.

For more details, visit Tsunan Sake.

About Space Seed Holdings

Space Seed Holdings, dedicated to transforming science fiction into reality, engages in investment and research to support the practical implementation of fermentation and longevity technologies. They aim to provide essential technologies for human habitation in space by 2040, collaborating with various stakeholders.

For further insights, visit Space Seed Holdings.