#Japan #Tokyo #lipid nanoparticles #RNA Drugs #CMC Research

Discovering LNP in RNA Drug Development

On May 13, 2025, CMC Research will host an insightful seminar titled "Fundamental and Applied Aspects of LNP as RNA Drug Delivery Technology". This event will begin at 1:30 PM and will be conducted via Zoom. The renowned lecturer, Professor Hidemaru Akita from Tohoku University’s Graduate School of Pharmaceutical Sciences, will guide attendees through the intricate world of lipid nanoparticles (LNP), a pivotal component in RNA drug delivery systems.

Seminar Insights

This seminar aims to equip participants with essential knowledge, including:

• - A brief history of LNP development up to the present.
• - Insights into lipid designs used in RNA vaccines.
• - Strategies for regulating bioavailability concerning RNA drug development.
• - Understanding mechanisms that activate immunity in RNA vaccines.

Whether you’re a novice aiming to grasp the concepts behind LNP or seeking to delve into trends in LNP development, this seminar offers an excellent opportunity to deepen your knowledge.

Event Details

Date: May 13, 2025
Time: 1:30 PM - 4:30 PM
Registration Fees:

• - General Attendance: 44,000 JPY (including tax, materials included)
• - Newsletter Subscribers: 39,600 JPY (including tax, materials included)
• - Academic Rate: 26,400 JPY (including tax, materials included)

Registration Process

To secure your spot, please register on the dedicated seminar page at CMC Research’s official website. Participants will receive a viewing URL via email for the event. Note that recording or photographing during the seminar is strictly prohibited.

Seminar Program

1. Introduction of the Speaker

2. Current Status of mRNA Drug Development

3. Designing Lipid Nanoparticles (LNP) for RNA Delivery

- The historical evolution from cationic lipids to pH-sensitive lipids
- Designing ionizable lipids and their efficiency in endosomal escape
- Recent functional strategies related to ionizable lipids

4. RNA Vaccines

- Technologies employed in COVID-19 vaccines
- Mechanisms for immune activation in RNA vaccine formulations
- Antigen presentation mechanisms associated with mRNA-LNP
- Insights on adverse reactions related to RNA vaccines

5. Applications of LNP

- Local and intravenous administration targeting the liver and beyond
- Utilizing DNA barcoding and lipid modification for cellular targeting

6. Additional Topics

- Manufacturing principles, structures of LNP, and an introduction to ready-to-use formulations

Meet the Speaker

Professor Hidemaru Akita
With a Ph.D. from the University of Tokyo, Professor Akita has made significant strides in the realm of RNA drug delivery, recognized for his innovative contributions through multiple academic awards. His involvement in societies such as the Japanese Society for Drug Delivery Systems and the Pharmaceutical Society of Japan highlights his expertise and commitment to advancing pharmaceutical sciences.

Don’t miss this exceptional opportunity to learn from a leading expert in the field! Register today to embark on your journey into the world of RNA drug development with LNP technologies.