Revolutionary Advances in Proteomics Unveiled by MOBILion Systems at HUPO 2025

MOBILion Systems Unveils Transformative Proteomics Advances at HUPO 2025

MOBILion Systems, Inc., a leader in separation technology, has announced its participation in the upcoming HUPO World Congress, showcasing its cutting-edge advancements in the field of proteomics. This significant event will take place from November 9 to 13, 2025, in Toronto, Canada. The company’s Chief Technology Officer, Daniel DeBord, will present innovative results related to the Parallel Accumulation Mobility Aligned Fragmentation (PAMAF™) technology, which promises to markedly improve sensitivity and throughput in mass spectrometry used for proteomics and multi-omics applications.

With the focus on post-translational modifications (PTMs) and proteoforms increasingly growing within the realm of proteomics research, the participants in the field are recognizing the need for superior detection accuracy and reliability that can transform how biological complexities are studied. The PAMAF technology developed by MOBILion facilitates nearly complete ion utilization, leading to extensive proteome coverage and enhanced analysis of PTMs and proteoforms. It achieves remarkable spectral generation rates exceeding 500 Hz through its high-speed high-resolution ion mobility (HRIM) separation process, diminishing reliance on traditional quadrupole filtration that tends to be slower and loss-prone.

Melissa Sherman, Ph.D., CEO of MOBILion Systems, emphasized the significance of these advancements, noting that in a field where incremental improvements are often seen as impactful, PAMAF provides explosion-like enhancements ranging from 300% to 2000% in ion fragmentation intensity. Such boosts are vital for researchers aiming to identify thousands of additional proteins and PTMs from smaller sample sizes, paving the way for new frontiers in proteomics, biomarker discovery, and therapeutic development.

During the conference, DeBord will share experimental data illustrating the integration of MOBILion’s MOBIE® HRIM module with existing QTOF platforms. These results have shown an up to 100-fold increase in ion fragmentation intensity, identifying three to twelve times more protein groups and yielding 43-53% more peptides per protein, mainly benefiting smaller input samples.

Moreover, the PAMAF mode is poised to revolutionize single-cell proteomics and quantitative PTM measurements. DeBord stated, "These findings highlight enhanced ion utilization as a crucial performance lever in mass spectrometry. By eliminating quadrupole filtration and aligning fragmentation with ion mobility, PAMAF enables a more comprehensive and unaltered analysis of complex biological samples, bringing us closer to full coverage of the proteome and proteoforms."

About MOBILion Systems, Inc.

MOBILion Systems is pioneering advanced analytical instruments that reveal molecular details previously obscured. By integrating structures for loss-free ion manipulation (SLIM) with high-resolution mass spectrometry, the company’s proprietary HRIM technology enhances resolution, sensitivity, and throughput in fields such as proteomics, metabolomics, lipidomics, and clinical research. MOBILion’s mission focuses on empowering scientists to expedite discoveries, improve precision medicine, and promote human health by making the invisible visible.

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Conclusion

MOBILion Systems is positioning itself at the forefront of proteomics research through innovative technology showcased at HUPO 2025. Researchers attending the conference can look forward to groundbreaking insights and advancements that could alter the landscape of biological research and medical diagnostics.