#India #Ashwagandha #Kerala #Shoden #Withanolide

New Insights Into Ashwagandha's Bioavailability

A groundbreaking clinical study has recently underscored the importance of withanolide glycosides in determining the bioavailability of ashwagandha extracts. Conducted by Arjuna Natural Pvt., Ltd., the research indicates that Shoden® ashwagandha, which boasts an impressive 35% concentration of these glycosides, exceeds the efficacy of other commercial extracts available in the market. This significant finding sheds light on the intricate relationship between the type of withanolides present and their respective absorption rates and effectiveness in the human body.

The Study Breakdown

Published in the notable journal Phytomedicine Plus last July, the randomized, open-label, crossover study involved 16 healthy participants who were administered various standardized ashwagandha extracts. Each extract was assessed for its composition and standardized to provide 185mg of total withanolides. The team, led by Priyank Rathi, MD, collected a total of 17 blood samples over a 24-hour window to evaluate how these different extracts impacted the subjects' plasma levels of withanolides.

The results were quite revealing. The extracts rich in withanolide glycosides showed a significantly higher level of systemic exposure compared to those with lower concentrations. Notably, Shoden achieved the highest scores in both absorption and pharmacokinetic profiles, demonstrating superior half-lives that indicate a longer and more effective circulation of active compounds within the body.

Implications for Quality Over Quantity

"Our findings signify a paradigm shift in the understanding of ashwagandha's effectiveness," stated Benny Antony, PhD, Joint Managing Director of Arjuna Natural. "This study illustrates that it isn't simply the total content of withanolides that matters; rather, the specific composition and the types of withanolides, particularly glycosides, are fundamental to enhancing absorption and achieving maximum therapeutic effects."

This research highlights why extract composition is crucial and underscores the importance of sourcing practices. Shoden is derived from validated ashwagandha sources and employs a proprietary extraction method to maintain its potency, even at a lower dosage of 60 mg.

Historical Significance and Future Prospects

Ashwagandha, often labeled "Indian ginseng," has been a staple in Ayurvedic medicine for centuries, revered for its rejuvenating properties. Recognized for its ability to support resilience and vitality, ashwagandha also contributes to mental wellness and possesses notable antioxidant, anti-inflammatory, and immunomodulatory qualities. However, varying profiles and manufacturing processes of market-available Withania extracts previously posed challenges, leading to inconsistencies in absorption and therapeutic efficacy.

Now, as ashwagandha's popularity continues to skyrocket for its stress-relieving and cognitive benefits, this study emphasizes the necessity for robust consumer education about the distinct profiles of withanolides.

The findings pave the way for future clinical research dedicated to assessing the concentration of specific glycosides, ultimately aiming to facilitate more effective formulations and standardizations that extend beyond mere totals of withanolide content. Shoden is already recognized globally, boasting 23 patents as a result of its unique formulation.

Conclusion

With three distinct doses and an array of supplement formats available—including powders, capsules, and pills—Shoden's low-dose formulation integrates seamlessly into functional foods and beverages, offering convenience without compromising potency. As it showcases its role in managing stress, enhancing quality of sleep, and boosting immune markers, Shoden stands out as a pivotal player in the growing landscape of health supplements.

In conclusion, as researchers like Antony advocate for clarity in labeling and the prioritization of specific withanolide profiles, it is evident that Shoden® ashwagandha is leading the charge toward better bioavailable solutions in natural health products.

Stay tuned as Arjuna Natural continues to unveil more about Shoden's positive effects and its growing role in holistic health practices, including upcoming presentations at major health and nutrition expos.