#Japan #Tokyo #Tohoku University #LiSH #Regenerosome

Exploring the Wellness Potential of Low Oxygen Environments: A New Clinical Trial

In an innovative collaboration, Regenerosome, a subsidiary of Space Seed Holdings based in Minato, Tokyo, has partnered with Tohoku University to conduct a pioneering clinical trial focusing on the health benefits of low oxygen environments. This study is taking place at the Wellness Healthcare demonstration hub, known as the Takanawa Gateway Link Scholars' Hub (LiSH), located in Tokyo's Minato ward.

The clinical trial aims to examine how prolonged exposure to low oxygen levels can potentially improve health metrics such as blood sugar levels and blood pressure, which have been indicated by previous research. Led by Assistant Professor Tsubasa Nakai from Tohoku University’s Graduate School of Medicine specializing in oxygen medicine, the study plans to monitor 20 adult participants. These individuals will spend 1 hour daily in a controlled hypoxic environment for four weeks, maintaining their regular work routines, including desk jobs and online meetings—a unique feature that underscores the practical applicability of the intervention.

During this trial, the research will include continuous monitoring of participants’ blood sugar levels and blood pressure to gather data on the hypoxic intervention’s direct impacts. Additionally, a new verification process will assess aging indicators through DNA methylation information sourced from saliva samples, using a metric known as the epigenetic clock, thereby adding a novel layer to their research scope.

The overarching goal of this trial is to elucidate how a low oxygen environment can influence daily life, specifically aimed at regulating blood sugar and blood pressure while evaluating aging markers. The findings could pave the way for future preventative healthcare practices as well as broader wellness applications in society.

Kickoff Event for the Hypoxia Wellness Trial

To celebrate the commencement of this research, a kickoff event titled “Hypoxia Wellness – Verification Trial Launch” is scheduled for October 6, 2025, at LiSH. During the event, attendees will gain insights into the research, experience the low oxygen space firsthand, and engage in networking opportunities with fellow participants.

Event Details:

• - Date: October 6, 2025
• - Time: Doors open at 15:45, event starts at 16:00 (LiSH 6th-floor workshop room)

- Overview of Regenerosome
- Detailed explanation of the trial by Associate Professor Nakai
- Tour and experience of the low oxygen space
- Additional guest lectures (to be confirmed)

• - Closure: 18:00
• - Social Hour: 18:30 (within LiSH)

Venue:

The Linkpillar 1 North LiSH, 6th Floor Workshop Room, Minato, Tokyo, conveniently located adjacent to JR Takanawa Gateway Station.

Participation Criteria:

The event is open to investors, press members, and invited guests (LiSH internal personnel). Verification of affiliation or invitation may be necessary.

For more details and to register for the event, please visit the Peatix event page.

About LiSH

LiSH (Link Scholars’ Hub) serves as one of Japan’s premier experimental platforms, focusing on environment, mobility, and healthcare to accelerate the implementation of new societal solutions. It fosters a collaborative space for startups, researchers, and enterprises to work together toward achieving urban wellness in the future. More information can be found at LiSH website.

About Regenerosome

Regenerosome aims to provide novel solutions for delaying aging and advancing regenerative medicine using nanostructured exosomes. The company is committed to detailed analyses of exosome functions and designing nanomaterials at a molecular biology level, ultimately aiding healthcare technology advancements and proposing new solutions in space medicine. For additional information, visit Regenerosome.

About Space Seed Holdings

Space Seed Holdings operates with the mission of 'Turning Sci-Fi into Non-Fiction' through investment, research activities, and business development in deep tech related to space. Their initiatives include the 'Fermentation and Longevity Fund' program, focusing on social implementations of fermentation and longevity technologies to solve societal challenges. By 2040, they aim to collaborate with various stakeholders to equip humanity with the necessary technologies for living in space. For further details, explore Space Seed Holdings.