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NASH/MASH Treatment Market Poised for Explosive Growth by 2033

The treatment landscape for Non-Alcoholic Steatohepatitis (NASH), now referred to as Metabolic Dysfunction–Associated Steatohepatitis (MASH), is undergoing a significant transformation. According to a report by DataM Intelligence, the NASH/MASH treatment market was valued at USD 7.87 billion in 2024 and is expected to soar to USD 31.76 billion by 2033, reflecting a robust compound annual growth rate (CAGR) of 17.7% from 2025 through 2033.

Key Drivers of Market Growth

A multitude of factors contributes to this dramatic market expansion. One of the primary drivers is the increasing prevalence of obesity, metabolic syndrome, and type 2 diabetes, which have become critical global health issues. Furthermore, an aging demographic is exacerbating these conditions, compelling a greater need for effective therapies.

The turning point for this market came in 2024 with the landmark approval of Resmetirom (marketed as Rezdiffra). This first-in-class therapy targets MASH by focusing on histological improvement and fibrosis reduction. The approval not only marked a milestone in treatment availability but also sparked intensified competition within the pharmaceutical industry, leading to accelerated investments in drug pipelines.

Market Demand and Growth Forecast

With the soaring demand for effective treatments, the approved drug category alone achieved a market valuation of about USD 178.31 million in 2024 and is projected to reach USD 16.82 billion by 2033. This category is witnessing one of the fastest growth rates, expected at an extraordinary 57.05% CAGR. Notably, over 80% of late-stage pipeline candidates are innovative therapies focusing on metabolic and fibrotic mechanisms, introducing therapies such as GLP-1 agonists, PPAR agonists, and dual agonists to redefine treatment possibilities.

MASH Prevalence and Patient Demographics

MASH represents a significant public health concern, affecting approximately 1 in 5 adults globally, with the highest prevalence rates noted in the U.S., China, and parts of Europe. Despite the high burden of the disease, the absence of effective treatments historically hampered market growth. However, with therapeutic options now available, the landscape has changed dramatically.

For instance, critical growth drivers include:

• - An anticipated global obesity population surpassing 1.9 billion by 2030.
• - The type 2 diabetes population expected to climb to 643 million by 2030.
• - Enhanced non-invasive diagnostics that facilitate early detection and treatment.
• - A strong demand from healthcare professionals for therapies that can effectively reverse steatohepatitis and fibrosis.

By 2030, the market is expected to introduce between 8 to 10 new drug classes, supporting both combination therapy and specific treatment approaches.

Market Segmentation Insights

The market segmentation paints a diverse picture:

• - By Drug Type: Resmetirom leads with early commercial success, while other drugs like Lanifibranor and Semaglutide are set to combat its market share in the coming years.
• - By Stage of Disease: Stage 2-3 fibrosis made up more than 52% of the market in 2024.
• - By Age Group: Adults represented 83%, while geriatric patients accounted for 14% of the market share in 2024.
• - By Gender: Male patients accounted for 56% of the treatment market, while females made up 44%.

Competitive Landscape and Key Players

Leading the charge in the approved MASH market is Madrigal Pharmaceuticals, followed closely by other industry giants like Novo Nordisk, Boehringer Ingelheim, and 89bio. These players are engaged in developing innovative therapies that not only address the metabolic dysfunction associated with MASH but also enhance patients' quality of life. Entrepreneurship in the field is fostering rapid advances in treatment options, ultimately benefiting patients worldwide.

Future Outlook

The MASH treatment sector is poised for momentous changes between 2025 and 2033, including the emergence of multi-drug combination therapies, increased demand for treatments in regions like the U.S., Japan, and China, and significant investments surpassing USD 30 billion in research and development activities. By 2033, MASH is anticipated to solidify its position as one of the largest non-oncology drug markets, paving the way for a new era in metabolic disease treatment.

As the healthcare landscape continues to evolve, the strides made in the MASH treatment market will not only lead to business growth but also result in improved health outcomes for patients worldwide. Companies that prioritize innovation and adaptability stand to benefit the most as they navigate the evolving demands of this vital sector.