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Pillar Biosciences and Hamilton Company Launch Automated NGS Library Preparation Method

In a significant advancement for myeloproliferative neoplasm (MPN) research, Pillar Biosciences, Inc. in collaboration with the Hamilton Company, has announced the successful validation and release of an automated next-generation sequencing (NGS) library preparation method. This new innovation enhances the capabilities of researchers studying MPN by streamlining workflows and ensuring faster results for critical genetic testing.

The newly designed method utilizes the Hamilton Microlab® STAR™ liquid handling system to automate the library preparation process of Pillar's research-use-only oncoReveal® Essential MPN panel. This rapid 3-gene NGS panel is specifically tailored to evaluate common mutations associated with MPN, focusing on the JAK2, CALR, and MPL genes. As part of this collaboration, the automated NGS library preparation method is the first of its kind to optimize such libraries with full automation.

Enhanced Efficiency and User Experience

One of the standout features of this automated NGS library preparation method is its ability to process up to 96 NGS libraries continuously in a single run. Key advantages include:

• - Efficient Sample Processing: By leveraging synchronous on-deck operations and the Multi-Probe Head (MPH) technology, the new method significantly cuts down sample processing time.
• - Flexible Throughput: Researchers can choose to run from 8 to 96 libraries in multiples of 8, providing flexibility based on project needs.
• - User-Friendly Interface: An intuitive user interface offers clear guidance through every procedure step, catering to various experience levels in laboratory environments.
• - Streamlined Workflow: The method reduces hands-on time for sample and reagent preparations, eliminating the need for mandatory mid-run tip reloads.
• - Economical Reagent Usage: With optimized pipetting, the method minimizes dead volume and reagent waste, promoting cost-effectiveness.

Joseph Goffreda, Automation Specialist from Pillar Biosciences, highlighted the rising global demand for automation in performing rapid NGS kitted panels. He stated, "The oncoReveal NGS Kits powered by Pillar's proprietary SLIMamp® enrichment chemistry are ideally suited for high-throughput automation, simplifying NGS workflows and producing rapid and precise results."

Collaboration Significance and Future Aspirations

Michael Mouradian, Vice President of Scientific Strategy and Market Development at Hamilton, expressed enthusiasm over this collaboration's first significant milestone. He remarked, "By integrating Pillar’s straightforward and robust NGS library preparation process with the speed and reach of our NGS STAR liquid handling systems, we are equipping researchers with a faster, more accessible, and efficient solution to advance MPN research and potentially across various additional applications."

The successful launch of this automated NGS library preparation method highlights the potential for innovation in laboratory automation and its impact on genetic research. It not only enhances the accuracy and efficiency of result generation but also addresses broader healthcare objectives in personalized medicine.

About Pillar Biosciences

Pillar Biosciences leads the way in Decision Medicine™, utilizing advanced sequencing technology to optimize therapy choices for cancer patients through data-driven insights. Their NGS solutions, underpinned by proprietary technologies such as SLIMamp® and PiVAT®, enhance access to vital diagnostic procedures while lowering related costs, contributing to more efficient patient care. With over 20 NGS testing kits currently available, Pillar is dedicated to expanding its offerings and refining the testing experience for clinicians and patients worldwide.

About Hamilton

Hamilton stands as a premier global manufacturer of automated liquid handling technologies, providing critical support to the scientific community in life sciences, clinical diagnostics, and beyond. Their innovative product offerings, rooted in reliability and performance, signify Hamilton's commitment to advancing laboratory automation and improving workflows in diverse research settings. With state-of-the-art manufacturing facilities and a focus on quality, Hamilton continues to set benchmarks in laboratory technology that help propel scientific discoveries forward.

In conclusion, Pillar Biosciences and Hamilton’s collaborative efforts not only represent a technological breakthrough in NGS library preparation but also unveil new possibilities for improving research methodologies in understanding and treating myeloproliferative neoplasms. As more laboratories embrace such automation, the pace of discovery in healthcare and translational medicine is expected to accelerate significantly.