Ceglu™ Multiwell Plates: A Breakthrough in Cell Culture
Sekisui Chemical Co., Ltd., led by President Keita Kato, has officially launched its Ceglu™ Multiwell Plates on June 30. This innovative product features a chemically synthesized cell adhesion polymer ideal for the stable culture of stem cells, including iPS cells. With its numerous advantages, it aims to enhance the quality and reliability of cell cultures, providing unique value ranging from laboratory scale to large-scale manufacturing in the field of regenerative medicine.
1. Background
Despite advances in modern medicine, challenges such as rare diseases, aging populations, and injuries persist. Regenerative medicine, particularly therapies utilizing iPS cells, holds great promise in addressing these health issues. iPS cells can be derived from a patient's own cells, minimizing the risk of rejection, and they are capable of differentiating into various cell types. However, effective culturing of iPS cells requires specialized cell adhesion coatings. Existing protein-based coatings faced challenges related to homogeneity and stability, posing significant obstacles to the practical application of regenerative medicine.
2. Development Journey
To tackle these issues, Sekisui Chemical developed Ceglu™, a new polymer that combines chemical synthesis with cell adhesion molecules to overcome the shortcomings of traditional protein coatings. The development process involved collaboration with institutions such as the Kyoto University Institute for Integrated Cell-Material Sciences and the Kyoto University iPS Cell Research Fund. By employing advanced chemical synthesis techniques, Ceglu™ achieves remarkable homogeneity and stability, creating an optimal environment for iPS cell culture. This groundbreaking product is set to redefine possibilities in the regenerative medicine landscape.
3. Overview of Ceglu™
Ceglu™ is a chemically synthesized polymer capable of coating surfaces of various materials. It boasts superior stability at room temperature compared to protein coatings, eliminating the need for cold chain logistics. Furthermore, with no animal components, Ceglu™ offers high safety standards. The polymer solution and coated Ceglu™ Multiwell Plates promise to establish a cohesive cell adhesion platform that spans both lab-scale and manufacturing-scale applications. Practical use cases include differentiation into iPS-derived cardiomyocytes, enhanced reproducibility of cell quality through automated culture systems, and scaling up cell cultures via coatings on nonwoven fabrics and microcarriers.
4. Future Developments
Ceglu™ Multiwell Plates will be marketed through Sekisui Medical Co., Ltd. For inquiries regarding this innovative product, use the contact details below:
Sales Inquiries:
Sekisui Medical Co., Ltd.
Drug Discovery Support Sales Division
Email: smd-adme@sekisui.com
Technical Inquiries:
Sekisui Chemical Co., Ltd.
Life Science Business Development Division
Email: support_life@sekisui.com
Additional Information
Ceglu™ derives its name from a combination of “Cell” and “Glue,” encapsulating its function as a cell adhesion polymer with excellent storage stability and adhesion capabilities suitable for culturing iPS cells and mesenchymal stem cells. This unique product is synthesized without any animal-derived ingredients during manufacturing, ensuring a clean and reliable environment for homogeneous cell culture surfaces.
For more details, visit our product webpage:
Ceglu™ Product Website