#USA #Boston #Volta Labs #Callisto #Twist Bioscience

Introduction

On October 9, 2025, Volta Labs proudly announced the launch of their innovative automated hybridization capture workflow, specifically designed for the Twist Standard Hybridization v2 Kit, utilizing their cutting-edge Callisto platform. This product promises to enhance the efficiency and consistency of next-generation sequencing (NGS) sample preparation, marking a significant advancement in genomic research methodologies.

Collaborating for Innovation

The development of this hybridization capture workflow is a joint effort between Volta Labs and Twist Bioscience. Both companies are well-regarded in the genomics sector, with Volta Labs recognized for its pioneering work in NGS sample preparation solutions. The integration of Twist's leading hybrid capture chemistry with Callisto's automated platform offers researchers and clinical laboratories a valuable tool for achieving reliable performance while simplifying complex workflows.

Udayan Umapathi, CEO of Volta Labs, emphasized the importance of this collaboration, stating, "By combining Twist's proven v2 kit with Callisto's unique architecture for precise temperature-controlled automation, we've streamlined the hybrid capture workflow, delivering consistently uniform enrichment in a solution that's simple, reliable, and easy to use for any lab."

Advantages of Callisto for Hybrid Capture

Hybridization capture plays a vital role in targeted sequencing applications, especially when it comes to large panels or identifying novel variants. Traditionally, these processes are labor-intensive and require specialized expertise. The Callisto platform addresses these challenges.

Callisto’s unique design features precise magnetic bead manipulation and continuous, uniform temperature control during the hybrid capture process. This precision ensures consistent enrichment performance and eliminates variability often found in manual or semi-automated methods.

With Callisto, labs can expect a fully automated, walk-away solution for hybrid capture, making the workflow significantly easier to manage. This system minimizes the frequency of repeat runs, thus helping laboratories reduce their overall sequencing costs while ensuring even coverage across various panels.

Benefits of the Twist Standard Hybridization v2 Kit

Twist Bioscience's capability to synthesize DNA at scale on a silicon platform allows them to create NGS tools with remarkable uniformity. Their Standard Hybridization v2 Kit is engineered to deliver uniform coverage and high sensitivity across the specified regions of interest.

Emily M. Leproust, CEO and co-founder of Twist Bioscience, stated, "We've built our Twist NGS tools to empower customers to accelerate their research and reduce downstream sequencing costs. By pairing our Twist Standard Hybridization v2 Kit with Callisto's automated platform, we're streamlining workflows for customers, enabling them to achieve exceptional performance and efficiency."

Conclusion

The introduction of the automated hybridization capture workflow by Volta Labs represents a significant breakthrough in genomic applications. This collaboration with Twist Bioscience is set to transform the landscape of next-generation sequencing, offering labs a reliable and efficient solution for sample preparation that enhances research capabilities while reducing operational costs.

For further information about this new tool and how it can benefit your laboratory, visit the Twist Hybrid Capture App page on Volta Labs' website.

About Volta Labs

Volta Labs specializes in genomics applications, focused on developing a state-of-the-art digital fluidics platform aimed at optimizing sample preparation in genomics. For more details about their innovative products and services, please check their official website.