#USA #Bethlehem #Bioprocess #ABEC #Process Sciences

ABEC Expands Process Sciences Group to Enhance Bioprocess Optimization

ABEC, a global frontrunner in bioprocess engineering solutions, has officially expanded its Process Sciences group. This strategic move aims to bolster biopharmaceutical manufacturers' abilities to accelerate development, reduce associated risks, and optimize productivity throughout the bioprocess lifecycle.

The Process Sciences team integrates a wealth of expertise in chemical and bioengineering. They employ advanced modeling techniques, experimental testing, and tailor-designed equipment to support clients from the initial stages of development all the way to commercial production. By merging hands-on experimentation with sophisticated computational tools, ABEC is pushing the envelope of bioprocessing, enabling quicker troubleshooting, efficient scale-up, and consistent technology transfer while preserving product quality and consistency.

A fundamental element of ABEC’s Process Sciences methodology revolves around a comprehensive understanding of processes. Their engineers meticulously analyze and optimize crucial parameters such as mass transfer, agitation, blend time, shear, and CO₂ stripping. This systematized approach is designed to meet specific process goals and navigate common mixing and scale-up challenges. Their extensive expertise covers both microbial fermentation and animal cell culture processes, enabling ABEC to deliver customized solutions tailored to a broad array of biomanufacturing applications.

To further support process validation, ABEC boasts dedicated facilities that conduct real-world mixing studies and live cell or microbial operations at scales ranging from 200mL to an impressive 6,000 liters. These hands-on activities are enhanced by Computational Fluid Dynamics (CFD) and other modeling tools that generate data crucial for supporting Quality by Design initiatives and the comprehensive characterization of processes.

The advanced CFD simulations serve to dramatically cut down development times and costs by minimizing the need for extensive experimental runs, thus de-risking decisions related to scale-up and technology transfers. Rather than conforming their processes to standard equipment, ABEC strategically designs systems around clearly defined process requirements, enabling a more flexible and effective manufacturing environment.

Scott Pickering, ABEC's spokesperson, articulated the essence of their Process Sciences offering: "This initiative provides our customers with the utmost confidence as they transition from development phases into production. By integrating modeling, experimental validation, and custom equipment design, we are able to optimize performance, elevate yield, and mitigate uncertainties often associated with bioprocessing."

About ABEC: Established in 1974, ABEC has stood as a beacon of engineered process solutions and services within the global biotech arena. Their clientele includes numerous pharmaceutical and biotech giants, many of whom rely on ABEC-engineered equipment and processes for the manufacture of leading therapies. The value that ABEC brings is grounded in their extensive experience, comprehensive in-house capabilities, and a commitment to a flexible, custom approach that effectively reduces costs and accelerates time to market, all while maximizing productivity.